Padres vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 4:12 a.m.

The San Diego Padres versus the Minnesota Twins is on the MLB schedule for Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Padres vs Twins Game Info

• San Diego Padres (69-60) vs. Minnesota Twins (63-66)
• Date: Saturday, August 22, 2026
• Time: 8:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Twins.TV

Padres vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-164) | MIN: (+138)
• Spread: SD: -1.5 (+136) | MIN: +1.5 (-164)
• Total: 8 -- Over: (-114) | Under: (-106)

Padres vs Twins Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 5-7, 3.18 ERA vs Dean Kremer (Twins) - 2-4, 5.40 ERA

The Padres will give the nod to Casey Mize (5-7) versus the Twins and Dean Kremer (2-4). Mize's team is 10-9-0 against the spread this season in his starts. Mize's team has won 50% of his starts when they are favored on the moneyline (5-5). The Twins have a 3-7-0 record against the spread in Kremer's starts. The Twins have been the underdog on the moneyline in seven of Kremer's starts this season, and they went 2-5 in those games.

Padres vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (60.5%)

Padres vs Twins Moneyline

• Minnesota is the underdog, +138 on the moneyline, while San Diego is a -164 favorite at home.

Padres vs Twins Spread

• The Padres are hosting the Twins and are favored by 1.5 runs (+136 to cover) on the runline. Minnesota is -164 to cover.

Padres vs Twins Over/Under

• The over/under for Padres-Twins on Aug. 22 is 8. The over is -114, and the under is -106.

Bet on San Diego Padres vs. Minnesota Twins on FanDuel today!

Padres vs Twins Betting Trends

• The Padres have come away with 31 wins in the 55 contests they have been listed as the favorites in this season.
• This season San Diego has come away with a win six times in 11 chances when named as a favorite of at least -164 on the moneyline.
• The Padres and their opponents have gone over the total this season in 56 of their 129 opportunities.
• In 129 games with a line this season, the Padres have a mark of 74-55-0 against the spread.
• The Twins have won 36 of the 79 games they were the underdog on the moneyline this season (45.6%).
• When it has played as a moneyline underdog with odds of +138 or longer, Minnesota has a record of 6-8 (42.9%).
• The Twins have had an over/under set by oddsmakers 126 times, and have combined with opponents to go over the total in 69 of those games (69-54-3).
• The Twins have a 69-57-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. has 140 hits and an OBP of .357 to go with a slugging percentage of .438. All three of those stats lead San Diego hitters this season. He has a .284 batting average, as well.
• Among qualifying hitters in the majors, he is 22nd in batting average, 37th in on-base percentage, and 59th in slugging.
• Tatis will look for his fourth straight game with a hit in this contest. In his last five games he is hitting .400 with two doubles, two home runs, a walk and six RBIs.
• Manny Machado is batting .217 with 20 doubles, 24 home runs and 58 walks. He's slugging .414 with an on-base percentage of .301.
• Among qualifying hitters, his batting average ranks him 128th, his on-base percentage 117th, and his slugging percentage 83rd.
• Jackson Merrill is batting .238 with a .405 slugging percentage and 63 RBI this year.
• Xander Bogaerts has been key for San Diego with 91 hits, an OBP of .318 plus a slugging percentage of .326.

Twins Player Leaders

• Josh Bell has a .430 slugging percentage, which paces the Twins. He's batting .257 with an on-base percentage of .321.
• Including all qualified hitters in MLB, he ranks 69th in batting average, 86th in on-base percentage and 62nd in slugging percentage.
• Brooks Lee is hitting .242 with 19 doubles, three triples, 18 home runs and 33 walks. He's slugging .416 with an on-base percentage of .297.
• He is currently 96th in batting average, 122nd in on-base percentage and 81st in slugging percentage among all qualifying hitters.
• Kody Clemens has 98 hits, a team-high for the Twins.
• Luke Keaschall paces his team with a .363 OBP.

Padres vs Twins Head to Head

• 8/21/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: +108)
• 8/31/2025: 7-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/30/2025: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2025: 7-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 11-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/20/2024: 7-5 SD (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/19/2024: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 5/11/2023: 5-3 MIN (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/10/2023: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2023: 6-1 SD (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

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