Red Sox vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 2:12 a.m.

The Boston Red Sox will take on the San Francisco Giants in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Red Sox vs Giants Game Info

• Boston Red Sox (69-59) vs. San Francisco Giants (52-76)
• Date: Saturday, August 22, 2026
• Time: 7:15 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: FOX

Red Sox vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-220) | SF: (+184)
• Spread: BOS: -1.5 (+106) | SF: +1.5 (-128)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Red Sox vs Giants Probable Starting Pitchers

Probable Pitchers: Patrick Sandoval (Red Sox) - 1-2, 4.76 ERA vs Blade Tidwell (Giants) - 0-0, 4.33 ERA

The Red Sox will give the nod to Patrick Sandoval (1-2, 4.76 ERA), who is eyeing win No. 2 on the season, and the Giants will counter with Blade Tidwell. When Sandoval starts, his team is 3-3-0 against the spread this season. Sandoval's team has won 75% of his starts when they are favored on the moneyline (3-1). When Tidwell starts, the Giants have gone 1-2-0 against the spread. The Giants were the moneyline underdog for two Tidwell starts this season -- they lost both.

Red Sox vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (58.2%)

Red Sox vs Giants Moneyline

• Looking at the moneyline for Giants-Red Sox, San Francisco is the underdog at +184, and Boston is -220 playing at home.

Red Sox vs Giants Spread

• The Giants are at the Red Sox, and are +1.5 on the runline. The Giants are +106 to cover the spread, and the Red Sox are -128.

Red Sox vs Giants Over/Under

• A combined run total of 8.5 has been set for Red Sox-Giants on Aug. 22, with the over at +102 and the under at -124.

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Red Sox vs Giants Betting Trends

• The Red Sox have been victorious in 46, or 52.9%, of the 87 contests they have been chosen as favorites in this season.
• This season Boston has come away with a win one time in three chances when named as a favorite of at least -220 on the moneyline.
• The Red Sox and their opponents have hit the over in 58 of their 126 games with a total set by oddsmakers this season.
• The Red Sox have posted a record of 62-64-0 against the spread this season.
• The Giants have won 28 of the 81 games they were listed as the moneyline underdog this season (34.6%).
• When playing as a moneyline underdog with odds of +184 or longer, San Francisco has gone 2-3 (40%).
• The Giants have combined with opponents to go over the total 59 times this season for a 59-57-9 record against the over/under.
• The Giants have put together a 56-69-0 record ATS this season (covering 44.8% of the time).

Red Sox Player Leaders

• Wilyer Abreu is batting .261 with 27 doubles, four triples, 22 home runs and 59 walks. He has an on-base percentage of .341 and a slugging percentage of .474.
• Among all qualifying hitters in baseball, he ranks 63rd in batting average, 57th in on-base percentage, and 32nd in slugging.
• Abreu hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .316 with a triple, five walks and three RBIs.
• Willson Contreras has 115 hits and an OBP of .396, both of which lead the Red Sox this season. He's batting .285 and slugging .541.
• He ranks 19th in batting average, second in on-base percentage and fourth in slugging in the majors.
• Contreras brings a four-game streak with at least one hit into this contest. During his last five outings he is hitting .389 with two doubles, two home runs, five walks and six RBIs.
• Ceddanne Rafaela leads Boston in slugging percentage (.462) powered by 51 extra-base hits.
• Caleb Durbin is batting .254 with a .324 OBP and 62 RBI for Boston this season.

Giants Player Leaders

• Rafael Devers has 31 doubles, a triple, 26 home runs and 55 walks while hitting .245. He's slugging .475 with an on-base percentage of .321.
• Including all qualified hitters, he ranks 90th in batting average, while his on-base percentage is 88th and he is 31st in slugging.
• Devers brings a three-game hitting streak into this game. During his last five outings he is hitting .263 with two doubles, two home runs, three walks and four RBIs.
• Jung Hoo Lee's .328 OBP and .430 slugging percentage both pace his team. He has a batting average of .291.
• His batting average ranks 11th among all qualified players, his on-base percentage ranks 78th, and he is 63rd in slugging.
• Willy Adames is batting .227 with 25 doubles, a triple, 20 home runs and 36 walks.
• Bryce Eldridge has 15 doubles, 14 home runs and 43 walks while hitting .248.

Red Sox vs Giants Head to Head

• 8/21/2026: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +158)
• 6/22/2025: 9-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/21/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/20/2025: 7-5 BOS (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/2/2024: 3-1 SF (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 6-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/30/2024: 4-0 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/30/2023: 4-3 SF (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/29/2023: 3-2 SF (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/28/2023: 3-2 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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