Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 1:12 a.m.

The MLB's Saturday slate includes the Houston Astros facing the Athletics.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Athletics Game Info

• Houston Astros (65-64) vs. Athletics (49-80)
• Date: Saturday, August 22, 2026
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-174) | OAK: (+162)
• Spread: HOU: -1.5 (+116) | OAK: +1.5 (-138)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 3-3, 3.67 ERA vs Jacob Lopez (Athletics) - 5-4, 5.22 ERA

The Astros will give the ball to Hunter Brown (3-3, 3.67 ERA), who is eyeing win No. 4 on the season, and the Athletics will turn to Jacob Lopez (5-4, 5.22 ERA). Brown's team is 6-7-0 against the spread this season in his starts. Brown's team has a record of 5-6 this season when he starts and they are the favorite on the moneyline. When Lopez starts, the Athletics have gone 8-9-0 against the spread. The Athletics have been the underdog on the moneyline in 15 of Lopez's starts this season, and they went 7-8 in those matchups.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.1%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -174 favorite, while the Athletics are a +162 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are +116 to cover, while the Athletics are -138 to cover.

Astros vs Athletics Over/Under

• The Astros-Athletics game on Aug. 22 has been given an over/under of 8.5 runs. The over is set at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have won in 28, or 50.9%, of the 55 contests they have been named as odds-on favorites in this year.
• This season, the Astros have come away with a win three times in eight chances when named as a favorite of at least -174 or better on the moneyline.
• The Astros and their opponents have hit the over in 68 of their 129 games with a total this season.
• In 129 games with a line this season, the Astros have a mark of 62-67-0 against the spread.
• The Athletics have a 33-59 record in games they were listed as the moneyline underdog (winning 35.9% of those games).
• The Athletics have a record of 4-9 when they have played as a moneyline underdog with odds of +162 or longer (30.8%).
• The Athletics have combined with their opponents to go over the total 64 times this season for a 64-63-2 record against the over/under.
• The Athletics have covered 45% of their games this season, going 58-71-0 ATS.

Astros Player Leaders

• Yordan Alvarez leads Houston with 147 hits and an OBP of .434, plus a team-best slugging percentage of .618. He's batting .321.
• Among qualified batters in the majors, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Alvarez will look for his fourth straight game with a hit in this matchup. In his last five games he is batting .313 with three doubles, a walk and two RBIs.
• Isaac Paredes is batting .262 with 23 doubles, a triple, 16 home runs and 50 walks, while slugging .426 with an on-base percentage of .356.
• He is 61st in batting average, 38th in on-base percentage and 68th in slugging in the major leagues.
• Paredes takes a three-game streak with at least one hit into this contest. In his last five games he is hitting .333 with two doubles, four walks and an RBI.
• Christian Walker has 106 hits this season and has a slash line of .233/.309/.442.
• Jeremy Pena is batting .283 with a .338 OBP and 40 RBI for Houston this season.

Athletics Player Leaders

• Jeff McNeil is hitting .261 with 16 doubles, six home runs and 25 walks. He's slugging .356 with an on-base percentage of .313.
• Zack Gelof has 12 doubles, a triple, 14 home runs and 20 walks while batting .265. He's slugging .474 with an on-base percentage of .325.
• Lawrence Butler has 13 doubles, a triple, 11 home runs and 45 walks while hitting .216.
• Carlos Cortes is batting .261 with 15 doubles, a triple, seven home runs and 27 walks.

Astros vs Athletics Head to Head

• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)

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