Bills vs Browns Predictions - NFL Preseason Prediction, Picks, Odds & Best Bets Today

NFL Betting Picks in Summary

• Shedeur Sanders 20+ Passing Yards
• Browns -2.5
• Under 36.5

Buffalo and Cleveland meet Saturday afternoon, and the prop board suggests a real shift from last week's quarterback plan in Cleveland.

All NFL preseason odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

Depth Chart Notes

Cleveland: Shedeur Sanders is the only Browns player with a posted prop this week. Last week, Deshaun Watson started and played the first half in his return from injury before Sanders took over for the second — the absence of any Watson market here suggests Sanders could be getting the start, or an expanded role, this time.

Buffalo: No Bills player has a live prop for this game, consistent with a backup-driven approach similar to what we've seen from Buffalo already this preseason.

NFL Predictions and Picks for Preseason Week 2

Buffalo Bills at Cleveland Browns (Sat, 1 p.m. ET)

Shedeur Sanders 20+ Passing Yards (+146)

Sanders got real live-game reps last week in relief of Watson, and with the only quarterback market on this board belonging to him, a plus-money price on 20 yards looks fair for an expanded workload.

Browns -2.5 (-124)

A confirmed quarterback market for Cleveland against a Bills side with no posted props of its own points to Cleveland having the clearer plan heading into this one.

Under 36.5 (-114)

A backup-driven Bills lineup against Cleveland's own reserves outside the quarterback spot points toward a lower-event, grind-it-out kind of afternoon.