Phillies vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 1:12 a.m.

In MLB action on Saturday, the Philadelphia Phillies face the St. Louis Cardinals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Cardinals Game Info

• Philadelphia Phillies (71-58) vs. St. Louis Cardinals (66-64)
• Date: Saturday, August 22, 2026
• Time: 6:05 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and Cardinals.TV

Phillies vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-132) | STL: (+112)
• Spread: PHI: -1.5 (+164) | STL: +1.5 (-200)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Phillies vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Painter (Phillies) - 2-8, 6.43 ERA vs Quinn Mathews (Cardinals) - 0-1, 3.00 ERA

The Phillies will give the ball to Andrew Painter (2-8, 6.43 ERA), who is eyeing win No. 3 on the season, and the Cardinals will turn to Quinn Mathews (0-1, 3.00 ERA). Painter and his team have a record of 2-14-0 against the spread when he starts. Painter's team has a record of 5-4 this season when he starts and they are the favorite on the moneyline. Mathews has started two games with set spreads, and the Cardinals failed to cover in both opportunities. The Cardinals were named the moneyline underdog for one Mathews start this season -- they lost.

Phillies vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.2%)

Phillies vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Phillies, St. Louis is the underdog at +112, and Philadelphia is -132 playing at home.

Phillies vs Cardinals Spread

• The Phillies are 1.5-run home favorites on the runline against the Cardinals. The Phillies are +164 to cover, and the Cardinals are -200.

Phillies vs Cardinals Over/Under

• An over/under of 8.5 has been set for Phillies-Cardinals on Aug. 22, with the over being -115 and the under -105.

Bet on Philadelphia Phillies vs. St. Louis Cardinals on FanDuel today!

Phillies vs Cardinals Betting Trends

• The Phillies have won in 60, or 64.5%, of the 93 contests they have been named as odds-on favorites in this year.
• Philadelphia has a record of 51-24 when favored by -132 or more this year.
• Contests with the Phillies have gone over the total set by oddsmakers in 58 of 125 chances this season.
• In 125 games with a line this season, the Phillies have a mark of 50-75-0 against the spread.
• The Cardinals have gone 40-45 in games they were listed as the moneyline underdog (winning 47.1% of those games).
• When playing as a moneyline underdog with odds of +112 or longer, St. Louis has a 24-27 record (winning 47.1% of its games).
• The Cardinals have played in 126 games with an over/under set, and have combined with opponents to go over the total 52 times (52-67-7).
• The Cardinals have a 68-58-0 record against the spread this season.

Phillies Player Leaders

• Bryce Harper has 116 hits this season and a team-best OBP of .379. He has a .257 batting average and a slugging percentage of .488.
• Among all qualified batters in MLB, he is 70th in batting average, ninth in on-base percentage, and 22nd in slugging.
• Luis Arraez has hit six homers this season while driving in 54 runs. He's batting .322 this season and slugging .444 with an on-base percentage of .355.
• He is first in batting average, 39th in on-base percentage and 52nd in slugging among qualified batters.
• Arraez has picked up at least one hit in eight straight games. In his last 10 games he is hitting .341 with three doubles, a home run, a walk and six RBIs.
• Bryson Stott is batting .262 with a .411 slugging percentage and 59 RBI this year.
• Kyle Schwarber has 111 hits, which ranks first among Philadelphia hitters this season, while batting .242 with 53 extra-base hits.

Cardinals Player Leaders

• Alec Burleson is batting .289 with 33 doubles, a triple, 21 home runs and 46 walks. He's slugging .489 with an on-base percentage of .355.
• Including all qualified hitters in the big leagues, he ranks 15th in batting average, 39th in on-base percentage and 21st in slugging percentage.
• Burleson brings an eight-game hitting streak into this matchup. In his last 10 outings he is hitting .342 with four doubles, two home runs, two walks and 12 RBIs.
• Jordan Walker has collected 143 hits while slugging .513. Both are team-highs. He has a batting average of .291 with an on-base percentage of .350.
• Including all qualified hitters, he is 11th in batting average, 45th in on-base percentage and 14th in slugging percentage.
• JJ Wetherholt is batting .241 with 14 doubles, 16 home runs and 62 walks.
• Ivan Herrera has a .360 OBP to lead his team.

Phillies vs Cardinals Head to Head

• 8/21/2026: 7-6 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +235)
• 8/12/2026: 7-1 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +150)
• 8/11/2026: 2-0 STL (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/10/2026: 6-5 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: +108)
• 5/14/2025: 14-7 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/12/2025: 3-2 STL (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/13/2025: 7-0 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/12/2025: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/11/2025: 2-0 STL (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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