Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 4:12 a.m.

The MLB schedule on Saturday includes the Arizona Diamondbacks taking on the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (68-61) vs. Cincinnati Reds (61-68)
• Date: Saturday, August 22, 2026
• Time: 8:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: Dbacks.TV and Reds.TV

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-174) | CIN: (+146)
• Spread: ARI: -1.5 (+125) | CIN: +1.5 (-150)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Mike Soroka (Diamondbacks) - 8-3, 2.93 ERA vs Rhett Lowder (Reds) - 4-8, 5.17 ERA

The Diamondbacks will call on Mike Soroka (8-3) versus the Reds and Rhett Lowder (4-8). Soroka's team is 9-7-0 against the spread in his starts this season. Soroka's team has won 70% of his starts when they are favored on the moneyline (7-3). The Reds have gone 9-10-0 against the spread when Lowder starts. The Reds are 8-8 in Lowder's 16 starts this season that they were the underdog on the moneyline.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (66%)

Diamondbacks vs Reds Moneyline

• Cincinnati is the underdog, +146 on the moneyline, while Arizona is a -174 favorite at home.

Diamondbacks vs Reds Spread

• The Reds are +1.5 on the run line against the Diamondbacks. The Reds are -150 to cover, and the Diamondbacks are +125.

Diamondbacks vs Reds Over/Under

• The over/under for the Diamondbacks versus Reds contest on Aug. 22 has been set at 8.5, with +100 odds on the over and -122 odds on the under.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have won in 31, or 59.6%, of the 52 contests they have been named as odds-on favorites in this year.
• This season Arizona has been victorious five times in six chances when named as a favorite of at least -174 on the moneyline.
• The Diamondbacks' games have gone over the total in 56 of their 128 opportunities.
• The Diamondbacks are 69-59-0 against the spread in their 128 games with a line set by sportsbooks this season.
• The Reds have been the underdog on the moneyline 84 total times this season. They've gone 39-45 in those games.
• Cincinnati has a record of 3-2 when it has played as a moneyline underdog with odds of +146 or longer (60%).
• The Reds have played in 126 games with a set over/under, and have combined with their opponents to go over the total 67 times (67-57-2).
• The Reds have collected a 66-60-0 record ATS this season (covering 52.4% of the time).

Diamondbacks Player Leaders

• Corbin Carroll has 116 hits, which ranks first among Arizona hitters this season, while batting .248 with 60 extra-base hits. He has an on-base percentage of .348 and a slugging percentage of .486.
• Among all qualified hitters in the majors, his batting average ranks 84th, his on-base percentage ranks 49th, and he is 24th in slugging.
• Carroll hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .250 with a double and four walks.
• Geraldo Perdomo has 18 doubles, six triples, nine home runs and 75 walks. He's batting .248 and slugging .376 with an on-base percentage of .357.
• Among qualifiers, he is 84th in batting average, 37th in on-base percentage and 115th in slugging percentage.
• Gabriel Moreno has 111 hits this season and a team-best OBP of .385.
• Moreno has recorded at least one base hit in 14 straight games. During his last 10 outings he is batting .357 with five doubles, a triple, two home runs, four walks and 12 RBIs.
• Nolan Arenado has been key for Arizona with 101 hits, an OBP of .321 plus a slugging percentage of .440.
• Arenado has hit safely in two games in a row. In his last five games he is batting .250 with two home runs, a walk and six RBIs.

Reds Player Leaders

• Sal Stewart has accumulated a team-high slugging percentage (.473) and paces the Reds in hits (127). He's batting .259 and with an on-base percentage of .334.
• Including all the qualified hitters in the big leagues, he ranks 66th in batting average, 67th in on-base percentage and 33rd in slugging percentage.
• Stewart hopes to build on a six-game hitting streak in this matchup. In his last 10 games he is hitting .289 with a double, two home runs, three walks and nine RBIs.
• Elly De La Cruz leads his team with a .340 on-base percentage. He has a batting average of .257 while slugging .463.
• Including all qualified hitters, he ranks 69th in batting average, 58th in on-base percentage and 39th in slugging percentage.
• JJ Bleday is hitting .217 with 13 doubles, a triple, 20 home runs and 59 walks.
• Matt McLain has 17 doubles, 12 home runs and 43 walks while batting .198.

Diamondbacks vs Reds Head to Head

• 8/21/2026: 9-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 6/14/2026: 5-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/13/2026: 2-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/12/2026: 5-2 ARI (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/24/2025: 6-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-1 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2025: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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