Yankees vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 11:12 p.m.

On Wednesday in MLB, the New York Yankees are up against the Pittsburgh Pirates.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Pirates Game Info

• New York Yankees (56-44) vs. Pittsburgh Pirates (52-49)
• Date: Wednesday, July 22, 2026
• Time: 1:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and SportsNet PT

Yankees vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-164) | PIT: (+138)
• Spread: NYY: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Yankees vs Pirates Probable Starting Pitchers

Probable Pitchers: Gerrit Cole (Yankees) - 3-5, 3.93 ERA vs Mitch Keller (Pirates) - 6-7, 5.14 ERA

The probable starters are Gerrit Cole (3-5) for the Yankees and Mitch Keller (6-7) for the Pirates. Cole and his team are 4-6-0 ATS this season when he starts. Cole's team has a record of 4-4 this season when he starts and they are the favorite on the moneyline. The Pirates have an 8-10-0 ATS record in Keller's 18 starts with a set spread. The Pirates have a 5-8 record in Keller's 13 starts this season when they were the underdog on the moneyline.

Yankees vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (53.4%)

Yankees vs Pirates Moneyline

• Looking at the moneyline for Pirates-Yankees, Pittsburgh is the underdog at +138, and New York is -164 playing at home.

Yankees vs Pirates Spread

• The Pirates are at the Yankees, and are +1.5 on the runline. The Pirates are +126 to cover the spread, and the Yankees are -152.

Yankees vs Pirates Over/Under

• Yankees versus Pirates, on July 22, has an over/under of 9.5, with the over being -105 and the under -115.

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Yankees vs Pirates Betting Trends

• The Yankees have been favorites in 80 games this season and have come away with the win 47 times (58.8%) in those contests.
• This season New York has been victorious 18 times in 28 chances when named as a favorite of at least -164 on the moneyline.
• The Yankees and their opponents have gone over the total this season in 43 of their 97 opportunities.
• The Yankees have an against the spread mark of 47-50-0 in 97 games with a line this season.
• The Pirates have put together a 20-25 record in games they were listed as the moneyline underdog (winning 44.4% of those games).
• In games it has played as a moneyline underdog with odds of +138 or longer, Pittsburgh has a record of 3-4 (42.9%).
• The Pirates have had an over/under set by bookmakers 99 times, and have combined with opponents to go over the total in 59 of those games (59-38-2).
• The Pirates have collected a 51-48-0 record ATS this season.

Yankees Player Leaders

• Ben Rice has 99 hits and an OBP of .372 to go with a slugging percentage of .594. All three of those stats are best among New York hitters this season. He has a .281 batting average, as well.
• Among all qualifying hitters in the majors, he is 32nd in batting average, 20th in on-base percentage, and second in slugging.
• Rice has recorded a base hit in 12 games in a row. In his last 10 games he is batting .405 with two doubles, a triple, four home runs, five walks and 11 RBIs.
• Cody Bellinger has 19 doubles, three triples, 11 home runs and 52 walks. He's batting .255 and slugging .416 with an on-base percentage of .344.
• His batting average ranks 76th among qualified players, his on-base percentage 58th, and his slugging percentage 86th.
• Bellinger takes a two-game streak with at least one hit into this matchup. In his last five games he is batting .353 with a double, two walks and an RBI.
• Trent Grisham has 62 hits this season and has a slash line of .226/.328/.412.
• Jazz Chisholm has been key for New York with 76 hits, an OBP of .304 plus a slugging percentage of .422.
• Chisholm has hit safely in five straight games. During his last five outings he is batting .368 with two doubles, three home runs and seven RBIs.

Pirates Player Leaders

• Bryan Reynolds has an on-base percentage of .399, a team-high for the Pirates. He's batting .282 and slugging .474.
• Including all qualifying players, he is 28th in batting average, while his on-base percentage ranks fifth and he is 38th in slugging.
• Brandon Lowe has collected 90 hits to lead his team. He has a batting average of .245 while slugging .478 with an on-base percentage of .313.
• Including all qualified hitters, his batting average puts him 95th, his on-base percentage is 104th, and he is 32nd in slugging.
• Ryan O'Hearn has 13 doubles, 16 home runs and 28 walks while hitting .281.
• Nick Gonzales is slugging .404 to pace his team.

Yankees vs Pirates Head to Head

• 7/20/2026: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2025: 5-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/5/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/4/2025: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/28/2024: 9-4 PIT (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/27/2024: 4-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/17/2023: 3-2 PIT (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/16/2023: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/15/2023: 7-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/21/2022: 14-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -295, Underdog Moneyline: +240)

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