Angels vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 11:12 p.m.

The MLB schedule on Wednesday includes the Los Angeles Angels taking on the St. Louis Cardinals.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Angels vs Cardinals Game Info

• Los Angeles Angels (40-61) vs. St. Louis Cardinals (51-48)
• Date: Wednesday, July 22, 2026
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and Cardinals.TV

Angels vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-122) | STL: (+104)
• Spread: LAA: +1.5 (-200) | STL: -1.5 (+164)
• Total: 9 -- Over: (-114) | Under: (-106)

Angels vs Cardinals Probable Starting Pitchers

Probable Pitchers: Reid Detmers (Angels) - 3-6, 4.16 ERA vs Michael McGreevy (Cardinals) - 4-7, 2.92 ERA

The Angels will give the nod to Reid Detmers (3-6, 4.16 ERA), who is eyeing win No. 4 on the season, and the Cardinals will turn to Michael McGreevy (4-7, 2.92 ERA). Detmers' team is 10-10-0 against the spread in his starts this season. Detmers' team is 3-2 this season when he starts and they are the moneyline favorite. The Cardinals have a 10-9-0 ATS record in McGreevy's 19 starts that had a set spread. The Cardinals have been the moneyline underdog in 14 of McGreevy's starts this season, and they went 7-7 in those matchups.

Angels vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Angels win (55.7%)

Angels vs Cardinals Moneyline

• St. Louis is a +104 underdog on the moneyline, while Los Angeles is a -122 favorite at home.

Angels vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Angels. The Cardinals are +164 to cover, while the Angels are -200 to cover as a 1.5-run underdog on the runline.

Angels vs Cardinals Over/Under

• The Angels-Cardinals contest on July 22 has been given an over/under of 9 runs. The over is set at -114 and the under at -106.

Bet on Los Angeles Angels vs. St. Louis Cardinals on FanDuel today!

Angels vs Cardinals Betting Trends

• The Angels have been chosen as favorites in 19 games this year and have walked away with the win 10 times (52.6%) in those games.
• This season Los Angeles has come away with a win four times in nine chances when named as a favorite of at least -122 on the moneyline.
• The Angels and their opponents have hit the over in 45 of their 100 games with a total set by oddsmakers this season.
• The Angels have posted a record of 53-47-0 against the spread this season.
• The Cardinals have been the underdog on the moneyline 69 total times this season. They've gone 33-36 in those games.
• In games it has played as a moneyline underdog with odds of +104 or longer, St. Louis has gone 25-25 (50%).
• In the 97 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 40 times (40-51-6).
• The Cardinals have a 55-42-0 record against the spread this season.

Angels Player Leaders

• Mike Trout leads Los Angeles with 69 hits and an OBP of .385 this season. He has a .232 batting average and a slugging percentage of .461.
• Among qualified batters in MLB, he is 118th in batting average, 11th in on-base percentage, and 49th in slugging.
• Zach Neto is batting .235 with 20 doubles, two triples, 19 home runs and 45 walks. He's slugging .444 with an on-base percentage of .325.
• Among all qualifying players, he is 114th in batting average, 84th in on-base percentage and 62nd in slugging percentage.
• Neto brings a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .200 with a walk and an RBI.
• Jo Adell has hit 14 homers with a team-high .393 SLG this season.
• Nolan Schanuel has been key for Los Angeles with 85 hits, an OBP of .353 plus a slugging percentage of .399.
• Schanuel heads into this matchup on a three-game hitting streak. In his last five games he is hitting .444 with three walks.

Cardinals Player Leaders

• Jordan Walker has totaled 109 hits with a .525 slugging percentage, both team-high statistics for the Cardinals. He's batting .292 and with an on-base percentage of .355.
• Including all the qualified hitters in MLB, he is 15th in batting average, 40th in on-base percentage and 13th in slugging percentage.
• Walker takes an 11-game hitting streak into this game. In his last 10 games he is batting .316 with three doubles, a home run, four walks and seven RBIs.
• Alec Burleson is hitting .277 with 23 doubles, a triple, 15 home runs and 33 walks. He's slugging .463 with an on-base percentage of .339.
• Including all qualifying players, his batting average places him 40th, his on-base percentage ranks 64th, and he is 48th in slugging.
• JJ Wetherholt has 10 doubles, 14 home runs and 42 walks while hitting .260.
• Ivan Herrera has a .370 OBP to lead his team.

Angels vs Cardinals Head to Head

• 7/20/2026: 3-2 LAA (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/2/2025: 12-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/1/2025: 9-7 LAA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 3/31/2025: 5-4 LAA (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/15/2024: 7-2 LAA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/14/2024: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/13/2024: 10-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/4/2023: 11-7 LAA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/3/2023: 6-4 LAA (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/2/2023: 5-1 LAA (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!