Mariners vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 11:13 p.m.

The Seattle Mariners versus the Cincinnati Reds is on the MLB schedule for Wednesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Mariners vs Reds Game Info

• Seattle Mariners (51-50) vs. Cincinnati Reds (45-54)
• Date: Wednesday, July 22, 2026
• Time: 3:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and Reds.TV

Mariners vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-118) | CIN: (+100)
• Spread: SEA: +1.5 (-205) | CIN: -1.5 (+168)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Mariners vs Reds Probable Starting Pitchers

Probable Pitchers: Emerson Hancock (Mariners) - 6-4, 3.17 ERA vs Brady Singer (Reds) - 4-9, 4.56 ERA

This contest's pitching matchup is set, as the Mariners will send Emerson Hancock (6-4) to the mound, while Brady Singer (4-9) will answer the bell for the Reds. Hancock's team is 7-11-0 against the spread in his starts this season. Hancock's team is 8-6 this season when he starts and they are the moneyline favorite. When Singer starts, the Reds are 11-7-0 against the spread. The Reds have a 6-10 record in Singer's 16 starts this season when they were the moneyline underdog.

Mariners vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (62.6%)

Mariners vs Reds Moneyline

• Looking at the moneyline for Reds-Mariners, Cincinnati is the underdog at +100, and Seattle is -118 playing at home.

Mariners vs Reds Spread

• The Reds are 1.5-run favorites against the spread for this matchup with the Mariners. The Reds are +168 to cover, while the Mariners are -205 to cover as a 1.5-run underdog on the runline.

Mariners vs Reds Over/Under

• The Mariners-Reds game on July 22 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

Bet on Seattle Mariners vs. Cincinnati Reds on FanDuel today!

Mariners vs Reds Betting Trends

• The Mariners have won in 46, or 54.1%, of the 85 contests they have been named as odds-on favorites in this year.
• Seattle has a record of 44-34 in contests when bookmakers favor them by -118 or more on the moneyline.
• Contests with the Mariners have gone over the total set by bookmakers in 48 of 100 chances this season.
• The Mariners have posted a record of 37-63-0 against the spread this season.
• The Reds are 29-36 in games they were listed as the moneyline underdog (winning 44.6% of those games).
• Cincinnati has gone 20-35 when playing as a moneyline underdog with odds of +100 or longer (36.4%).
• The Reds have combined with opponents to go over the total 55 times this season for a 55-41-1 record against the over/under.
• The Reds have collected a 52-45-0 record ATS this season (covering 53.6% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle with 96 hits and an OBP of .381, plus a team-best slugging percentage of .450. He's batting .284.
• He is 26th in batting average, 13th in on-base percentage, and 58th in slugging among qualified batters in the majors.
• Arozarena has recorded a base hit in two games in a row. During his last five outings he is batting .222 with a home run, a walk and three RBIs.
• Josh Naylor is batting .253 with 12 doubles, eight home runs and 31 walks, while slugging .351 with an on-base percentage of .317.
• Among qualifying hitters, his batting average places him 79th, his on-base percentage 94th, and his slugging percentage 131st.
• Naylor brings a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .278 with two walks and an RBI.
• Cole Young is batting .254 with a .406 slugging percentage and 48 RBI this year.
• Julio Rodriguez has been key for Seattle with 91 hits, an OBP of .320 plus a slugging percentage of .417.
• Rodriguez has safely hit in two straight games. In his last five games he is batting .313 with two walks and two RBIs.

Reds Player Leaders

• Sal Stewart has racked up a slugging percentage of .470, a team-high for the Reds. He's batting .251 with an on-base percentage of .331.
• Including all qualifying hitters in the majors, he is 81st in batting average, 75th in on-base percentage and 43rd in slugging percentage.
• Elly De La Cruz's 89 hits and .352 on-base percentage both pace his team. He has a batting average of .279 while slugging .502.
• Including all qualified hitters, his batting average places him 37th, his on-base percentage is 46th, and he is 21st in slugging.
• Spencer Steer is hitting .245 with 14 doubles, 16 home runs and 34 walks.
• JJ Bleday is batting .239 with 11 doubles, a triple, 16 home runs and 41 walks.

Mariners vs Reds Head to Head

• 7/20/2026: 8-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/17/2025: 11-7 SEA (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/15/2025: 8-4 CIN (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/17/2024: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2024: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/15/2024: 9-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/6/2023: 8-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/5/2023: 7-6 CIN (Favorite: Mariners, Spread: -1.5, Total: 10.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/4/2023: 6-3 CIN (Favorite: Mariners, Spread: -1.5, Total: 10.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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