Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:12 a.m.

The New York Yankees versus the Baltimore Orioles is on the MLB schedule for Friday.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Orioles Game Info

• New York Yankees (91-68) vs. Baltimore Orioles (75-84)
• Date: Friday, September 26, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: MLB Network, YES, and MASN

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-152) | BAL: (+128)
• Spread: NYY: -1.5 (+142) | BAL: +1.5 (-172)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 8-8, 4.35 ERA vs Trevor Rogers (Orioles) - 9-2, 1.35 ERA

The Yankees will give the nod to Will Warren (8-8, 4.35 ERA), who is eyeing win No. 9 on the season, and the Orioles will turn to Trevor Rogers (9-2, 1.35 ERA). Warren and his team are 12-20-0 ATS this season when he starts. Warren's team is 15-11 this season when he starts and they are the moneyline favorite. The Orioles are 12-4-0 ATS in Rogers' 16 starts with a set spread. The Orioles have a 7-3 record in Rogers' 10 starts this season when they were the moneyline underdog.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (52.8%)

Yankees vs Orioles Moneyline

• Looking at the moneyline for Orioles-Yankees, Baltimore is the underdog at +128, and New York is -152 playing at home.

Yankees vs Orioles Spread

• The Yankees are favored by 1.5 runs at home versus the Orioles. The Yankees are +142 to cover the spread, while the Orioles are -172.

Yankees vs Orioles Over/Under

• An over/under of 8.5 has been set for Yankees-Orioles on Sept. 26, with the over being -105 and the under -115.

Bet on New York Yankees vs. Baltimore Orioles on FanDuel today!

Yankees vs Orioles Betting Trends

• The Yankees have been favorites in 135 games this season and have come away with the win 82 times (60.7%) in those contests.
• New York has a record of 54-27 when favored by -152 or more this year.
• The Yankees and their opponents have gone over the total this season in 75 of their 157 opportunities.
• In 157 games with a line this season, the Yankees have a mark of 74-83-0 against the spread.
• The Orioles have gone 41-49 in games they were the underdog on the moneyline (winning 45.6% of those games).
• In games it has played as a moneyline underdog with odds of +128 or longer, Baltimore has a record of 11-20 (35.5%).
• The Orioles have played in 156 games with a set over/under, and have combined with opponents to go over the total 64 times (64-87-5).
• The Orioles are 75-81-0 ATS this season.

Yankees Player Leaders

• Aaron Judge has 175 hits and an OBP of .457 to go with a slugging percentage of .683. All three of those stats are tops among New York hitters this season. He has a .330 batting average, as well.
• Among qualifying hitters in the majors, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Judge hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .412 with a double, three home runs, seven walks and five RBIs.
• Cody Bellinger is hitting .269 with 25 doubles, five triples, 29 home runs and 55 walks, while slugging .480 with an on-base percentage of .331.
• Among all qualifying batters, he is 43rd in batting average, 70th in on-base percentage and 30th in slugging percentage.
• Bellinger enters this matchup looking to extend his two-game hit streak. In his last five games he is hitting .211 with five walks.
• Trent Grisham has collected 115 base hits, an OBP of .347 and a slugging percentage of .469 this season.
• Grisham has recorded a hit in two games in a row. In his last five games he is batting .190 with a home run, five walks and three RBIs.
• Jazz Chisholm is batting .245 with a .334 OBP and 80 RBI for New York this season.

Orioles Player Leaders

• Gunnar Henderson has accumulated 155 hits with a .348 on-base percentage and a .435 slugging percentage, all club-bests for the Orioles. He's batting .274.
• Including all qualified hitters, he ranks 33rd in batting average, while his on-base percentage is 41st and he is 69th in slugging.
• Jackson Holliday has 21 doubles, three triples, 17 home runs and 54 walks while hitting .245. He's slugging .381 with an on-base percentage of .316.
• He is 101st in batting average, 102nd in on-base percentage and 122nd in slugging percentage in the majors.
• Jordan Westburg is batting .260 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman has 16 doubles, two triples, nine home runs and 38 walks while batting .225.

Yankees vs Orioles Head to Head

• 9/21/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/28/2025: 4-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!