Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:13 a.m.

The Chicago Cubs versus the St. Louis Cardinals is on the MLB schedule for Friday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cubs vs Cardinals Game Info

• Chicago Cubs (89-70) vs. St. Louis Cardinals (78-81)
• Date: Friday, September 26, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-168) | STL: (+142)
• Spread: CHC: -1.5 (+118) | STL: +1.5 (-142)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 10-7, 4.10 ERA vs Miles Mikolas (Cardinals) - 8-10, 4.76 ERA

The probable pitchers are Colin Rea (10-7) for the Cubs and Miles Mikolas (8-10) for the Cardinals. Rea's team is 16-9-0 against the spread this season in his starts. Rea's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 9-6. The Cardinals have gone 14-16-0 against the spread when Mikolas starts. The Cardinals have been the moneyline underdog in 22 of Mikolas' starts this season, and they went 9-13 in those matchups.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.5%)

Cubs vs Cardinals Moneyline

• The moneyline numbers for Cubs vs. Cardinals reveal Chicago as the favorite (-168) and St. Louis as the underdog (+142) on the road.

Cubs vs Cardinals Spread

• The Cubs are hosting the Cardinals and are favored by 1.5 runs (+118 to cover) on the runline. St. Louis is -142 to cover.

Cubs vs Cardinals Over/Under

• The Cubs-Cardinals contest on Sept. 26 has been given an over/under of 8.5 runs. The over is set at -122 and the under at -100.

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Cubs vs Cardinals Betting Trends

• The Cubs have been victorious in 67, or 63.8%, of the 105 contests they have been chosen as favorites in this season.
• This year Chicago has won 24 of 36 games when listed as at least -168 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 72 of 154 chances this season.
• The Cubs are 72-82-0 against the spread in their 154 games that had a posted line this season.
• The Cardinals have compiled a 43-44 record in games they were listed as the moneyline underdog (winning 49.4% of those games).
• St. Louis has a 5-14 record (winning only 26.3% of its games) when it has played as a moneyline underdog of +142 or longer.
• The Cardinals have combined with opponents to go over the total 78 times this season for a 78-70-5 record against the over/under.
• The Cardinals have covered 51% of their games this season, going 78-75-0 ATS.

Cubs Player Leaders

• Nico Hoerner leads Chicago in slugging percentage (.393) thanks to 39 extra-base hits. He has a .299 batting average and an on-base percentage of .348.
• Among qualified hitters in MLB, he ranks eighth in batting average, 41st in on-base percentage, and 112th in slugging.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks. He's batting .244 and slugging .472 with an on-base percentage of .284.
• Among qualified hitters, he is 106th in batting average, 140th in on-base percentage and 40th in slugging percentage.
• Ian Happ is batting .242 with a .422 slugging percentage and 78 RBI this year.
• Happ takes a four-game hitting streak into this game. In his last five games he is hitting .211 with three doubles, two walks and four RBIs.
• Seiya Suzuki has been key for Chicago with 137 hits, an OBP of .323 plus a slugging percentage of .464.
• Suzuki has safely hit in four straight games. In his last five games he is batting .278 with a double, two home runs and six RBIs.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .464 and has 144 hits, both team-high figures for the Cardinals. He's batting .293 and with an on-base percentage of .345.
• Including all the qualifying hitters in the big leagues, his batting average ranks 12th, his on-base percentage is 47th, and he is 44th in slugging.
• Burleson enters this game on a nine-game hitting streak. During his last 10 outings he is hitting .421 with four doubles, a home run, three walks and six RBIs.
• Brendan Donovan's .353 on-base percentage leads his team. He has a batting average of .287 while slugging .422.
• His batting average ranks 17th among all qualified players, his on-base percentage is 33rd, and he is 78th in slugging.
• Ivan Herrera is hitting .286 with 13 doubles, 19 home runs and 43 walks.
• Lars Nootbaar is batting .237 with 24 doubles, a triple, 13 home runs and 62 walks.

Cubs vs Cardinals Head to Head

• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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