Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:11 a.m.

The Houston Astros versus the Los Angeles Angels is on the MLB schedule for Friday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Angels Game Info

• Houston Astros (85-74) vs. Los Angeles Angels (71-88)
• Date: Friday, September 26, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | LAA: (+124)
• Spread: HOU: -1.5 (+105) | LAA: +1.5 (-126)
• Total: 9 -- Over: (-110) | Under: (-110)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Jason Alexander (Astros) - 4-2, 4.83 ERA vs Kyle Hendricks (Angels) - 8-10, 4.79 ERA

The probable pitchers are Jason Alexander (4-2) for the Astros and Kyle Hendricks (8-10) for the Angels. Alexander's team is 8-4-0 against the spread in his starts this season. Alexander's team has won 83.3% of his starts when they are favored on the moneyline (5-1). The Angels have a 20-10-0 ATS record in Hendricks' 30 starts with a set spread. The Angels have an 11-14 record in Hendricks' 25 starts this season when they were the underdog on the moneyline.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.2%)

Astros vs Angels Moneyline

• Looking at the moneyline for Astros-Angels, Houston is the favorite at -146, and Los Angeles is +124 playing at home.

Astros vs Angels Spread

• The Astros are favored by 1.5 runs on the road versus the Angels. The Astros are +105 to cover the spread, while the Angels are -126.

Astros vs Angels Over/Under

• The Astros-Angels contest on Sept. 26 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been favorites in 96 games this season and have come away with the win 51 times (53.1%) in those contests.
• Houston has a record of 20-16 in contests when sportsbooks favor them by -146 or more on the moneyline.
• The Astros and their opponents have gone over in 72 of their 158 games with a total set by sportsbooks this season.
• The Astros are 78-80-0 against the spread in their 158 games that had a posted line this season.
• The Angels are 51-67 in games they were listed as the moneyline underdog (winning 43.2% of those games).
• Los Angeles is 30-37 (winning 44.8% of its games) when playing as a moneyline underdog of +124 or longer.
• The Angels have combined with opponents to go over the total 84 times this season for an 84-68-5 record against the over/under.
• The Angels are 82-75-0 ATS this season.

Astros Player Leaders

• Jose Altuve leads Houston with a slugging percentage of .443, fueled by 51 extra-base hits. He has a .265 batting average and an on-base percentage of .329.
• Among qualified hitters in baseball, his batting average ranks 52nd, his on-base percentage ranks 77th, and he is 63rd in slugging.
• Altuve has picked up at least one hit in two straight games. In his last five games he is batting .412 with two doubles, three walks and three RBIs.
• Jeremy Pena leads the Astros in OBP (.363) and total hits (150) this season. He's batting .304 while slugging .477.
• His batting average ranks fifth among qualified players, his on-base percentage 16th, and his slugging percentage 32nd.
• Yainer Diaz is batting .253 with a .408 slugging percentage and 68 RBI this year.
• Carlos Correa has 13 home runs, 52 RBI and a batting average of .274 this season.
• Correa brings a two-game hitting streak into this matchup. During his last five outings he is batting .222 with two doubles, four walks and two RBIs.

Angels Player Leaders

• Taylor Ward has accumulated a slugging percentage of .477, a team-high for the Angels. He's batting .228 with an on-base percentage of .315.
• He is 137th in batting average, 104th in on-base percentage and 32nd in slugging percentage among all qualifying hitters in MLB.
• Ward heads into this game on a seven-game hitting streak. In his last 10 games he is batting .282 with six home runs and six RBIs.
• Jo Adell has collected 122 hits to lead his team. He has a batting average of .237 while slugging .490 with an on-base percentage of .296.
• Including all qualifying hitters, he ranks 118th in batting average, 126th in on-base percentage and 21st in slugging percentage.
• Nolan Schanuel has accumulated a team-best .355 on-base percentage.
• Mike Trout has a .355 OBP to pace his team.

Astros vs Angels Head to Head

• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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