Brewers vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:13 a.m.

On Friday in MLB, the Milwaukee Brewers are playing the Cincinnati Reds.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Reds Game Info

• Milwaukee Brewers (96-63) vs. Cincinnati Reds (81-78)
• Date: Friday, September 26, 2025
• Time: 8:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FDSWI and FDSOH

Brewers vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-164) | CIN: (+138)
• Spread: MIL: -1.5 (+120) | CIN: +1.5 (-144)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Brewers vs Reds Probable Starting Pitchers

Probable Pitchers: Quinn Priester (Brewers) - 13-2, 3.25 ERA vs Zack Littell (Reds) - 10-8, 3.86 ERA

This contest's pitching matchup is set, as the Brewers will send Quinn Priester (13-2) to the mound, while Zack Littell (10-8) will take the ball for the Reds. When Priester starts, his team is 15-8-0 against the spread this season. When Priester starts a game and his team is the favorite on the moneyline, they have a record of 10-2. The Reds are 16-15-0 ATS in Littell's 31 starts that had a set spread. The Reds have been the underdog on the moneyline in 19 of Littell's starts this season, and they went 10-9 in those games.

Brewers vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (60.2%)

Brewers vs Reds Moneyline

• Cincinnati is a +138 underdog on the moneyline, while Milwaukee is a -164 favorite at home.

Brewers vs Reds Spread

• The Reds are +1.5 on the run line against the Brewers. The Reds are -144 to cover, and the Brewers are +120.

Brewers vs Reds Over/Under

• A combined run total of 8.5 has been set for Brewers-Reds on Sept. 26, with the over at -100 and the under at -122.

Bet on Milwaukee Brewers vs. Cincinnati Reds on FanDuel today!

Brewers vs Reds Betting Trends

• The Brewers have been chosen as favorites in 93 games this year and have walked away with the win 59 times (63.4%) in those games.
• This season Milwaukee has come away with a win 20 times in 25 chances when named as a favorite of at least -164 on the moneyline.
• The Brewers and their opponents have gone over the total this season in 78 of their 156 opportunities.
• The Brewers are 86-70-0 against the spread in their 156 games with a line set by sportsbooks this season.
• The Reds have compiled a 40-42 record in games they were listed as the moneyline underdog (winning 48.8% of those games).
• In games it has played as a moneyline underdog with odds of +138 or longer, Cincinnati has gone 9-12 (42.9%).
• The Reds have played in 150 games with an over/under set, and have combined with opponents to go over the total 58 times (58-82-10).
• The Reds have covered 52% of their games this season, going 78-72-0 ATS.

Brewers Player Leaders

• Brice Turang leads Milwaukee with an OBP of .357, plus a team-best slugging percentage of .434. He's batting .287 on the season.
• He is 17th in batting average, 24th in on-base percentage, and 72nd in slugging among qualified batters in baseball.
• William Contreras leads Milwaukee in OBP (.357) this season, fueled by 147 hits. He's batting .262 while slugging .402.
• His batting average ranks 61st among qualified players, his on-base percentage 24th, and his slugging percentage 100th.
• Christian Yelich has 149 hits this season and has a slash line of .266/.344/.456.
• Yelich has logged a hit or more in three games in a row. In his last five games he is batting .167 with three walks and two RBIs.
• Sal Frelick has been key for Milwaukee with 151 hits, an OBP of .355 plus a slugging percentage of .410.
• Frelick has hit safely in two straight games. In his last five games he is hitting .174 with a double, a home run and two RBIs.

Reds Player Leaders

• Elly De La Cruz has put up a slugging percentage of .439 and has 163 hits, both team-best marks for the Reds. He's batting .264 and with an on-base percentage of .337.
• He is 57th in batting average, 56th in on-base percentage and 66th in slugging percentage among all qualifying batters in the majors.
• TJ Friedl has a .363 on-base percentage to pace his team. He has a batting average of .259 while slugging .372.
• Including all qualifying hitters, his batting average puts him 71st, his on-base percentage is 16th, and he is 130th in slugging.
• Spencer Steer is batting .238 with 20 doubles, two triples, 21 home runs and 48 walks.
• Austin Hays is hitting .266 with 16 doubles, five triples, 15 home runs and 29 walks.

Brewers vs Reds Head to Head

• 8/17/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/16/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/15/2025: 10-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/4/2025: 9-1 MIL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/3/2025: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/2/2025: 3-2 MIL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/6/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 11-7 CIN (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/4/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/3/2025: 1-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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