Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 6:11 a.m.

In MLB action on Friday, the San Diego Padres face the Arizona Diamondbacks.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Diamondbacks Game Info

• San Diego Padres (87-72) vs. Arizona Diamondbacks (80-79)
• Date: Friday, September 26, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and ARID

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-142) | ARI: (+120)
• Spread: SD: -1.5 (+146) | ARI: +1.5 (-178)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.51 ERA vs Zac Gallen (Diamondbacks) - 13-14, 4.70 ERA

This contest's pitching matchup is set, as the Padres will send Yu Darvish (4-5) to the mound, while Zac Gallen (13-14) will take the ball for the Diamondbacks. Darvish's team is 9-4-0 against the spread in his starts this season. Darvish's team has been victorious in 71.4% of the games he's started as the moneyline favorite with a record of 5-2. The Diamondbacks have a 15-17-0 record against the spread in Gallen's starts. The Diamondbacks have been the underdog on the moneyline in 13 of Gallen's starts this season, and they went 7-6 in those games.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56%)

Padres vs Diamondbacks Moneyline

• Looking at the moneyline for Padres-Diamondbacks, San Diego is the favorite at -142, and Arizona is +120 playing on the road.

Padres vs Diamondbacks Spread

• The Padres are hosting the Diamondbacks and are favored by 1.5 runs (+146 to cover) on the runline. Arizona is -178 to cover.

Padres vs Diamondbacks Over/Under

• An over/under of 7.5 has been set for Padres-Diamondbacks on Sept. 26, with the over being -115 and the under -105.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have been victorious in 51, or 59.3%, of the 86 contests they have been chosen as favorites in this season.
• San Diego has a record of 34-25 when favored by -142 or more this year.
• The Padres and their opponents have gone over the total this season in 68 of their 157 opportunities.
• The Padres are 84-73-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Diamondbacks have won 49.3% of the games this season they were the moneyline underdog (33-34).
• Arizona has a 15-10 record (winning 60% of its games) when playing as a moneyline underdog of +120 or longer.
• The Diamondbacks have played in 155 games with a set over/under, and have combined with their opponents to go over the total 77 times (77-70-8).
• The Diamondbacks have put together a 78-77-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .267 with 27 doubles, two triples, 23 home runs and 88 walks. He has an on-base percentage of .367 while slugging .438.
• Among qualified hitters in the majors, he is 45th in batting average, 12th in on-base percentage, and 68th in slugging.
• Tatis has picked up at least one hit in five games in a row. During his last five outings he is hitting .381 with a home run, two walks and an RBI.
• Manny Machado leads San Diego with 166 hits. He is batting .273 this season and has 59 extra-base hits. He's also slugging .455 with an on-base percentage of .332.
• Among qualified hitters, he ranks 36th in batting average, 67th in on-base percentage and 55th in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.388) powered by 41 extra-base hits.
• Arraez has picked up a hit in 13 straight games. In his last 10 outings he is batting .333 with a home run, four walks and six RBIs.
• Ramon Laureano has been key for San Diego with 124 hits, an OBP of .342 plus a slugging percentage of .512.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a team-best OBP (.390) and slugging percentage (.457). He's batting .289.
• Including all the qualified players in MLB, his batting average is 15th, his on-base percentage ranks fourth, and he is 52nd in slugging.
• Corbin Carroll's 146 hits pace his team. He has a batting average of .260 while slugging .544 with an on-base percentage of .342.
• He is currently 66th in batting average, 53rd in on-base percentage and seventh in slugging percentage among all qualified hitters.
• Ketel Marte is batting .283 with 28 doubles, 26 home runs and 63 walks.
• Gabriel Moreno is hitting .284 with 12 doubles, a triple, nine home runs and 27 walks.

Padres vs Diamondbacks Head to Head

• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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