Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:12 a.m.

Friday's slate in the MLB includes a matchup between the Washington Nationals and the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Nationals vs White Sox Game Info

• Washington Nationals (65-94) vs. Chicago White Sox (58-101)
• Date: Friday, September 26, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-134) | CHW: (+114)
• Spread: WSH: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 9 -- Over: (-100) | Under: (-122)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Cavalli (Nationals) - 3-1, 4.23 ERA vs Yoendrys Gomez (White Sox) - 3-3, 4.92 ERA

The Nationals will give the nod to Cade Cavalli (3-1, 4.23 ERA), who is eyeing win No. 4 on the season, and the White Sox will counter with Yoendrys Gomez (3-3, 4.92 ERA). Cavalli and his team are 7-2-0 ATS this season when he starts. Cavalli's team won his only start as a favorite this season. The White Sox have gone 6-2-0 against the spread when Gomez starts. The White Sox have a 4-4 record in Gomez's eight starts this season when they were the underdog on the moneyline.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (55.8%)

Nationals vs White Sox Moneyline

• Washington is the favorite, -134 on the moneyline, while Chicago is a +114 underdog on the road.

Nationals vs White Sox Spread

• The Nationals are hosting the White Sox and are favored by 1.5 runs on the spread. The Nationals are +150 to cover the runline, with the White Sox being -182.

Nationals vs White Sox Over/Under

• Nationals versus White Sox on Sept. 26 has an over/under of 9 runs, with the odds on the over -100 and the under set at -122.

Bet on Washington Nationals vs. Chicago White Sox on FanDuel today!

Nationals vs White Sox Betting Trends

• The Nationals have won in six, or 33.3%, of the 18 contests they have been named as odds-on favorites in this year.
• Washington has a record of 2-6 in contests when bookmakers favor them by -134 or more on the moneyline.
• The Nationals and their opponents have hit the over in 81 of their 153 games with a total set by oddsmakers this season.
• In 153 games with a line this season, the Nationals have a mark of 76-77-0 against the spread.
• The White Sox have a 54-96 record in games they were listed as the moneyline underdog (winning 36% of those games).
• Chicago has gone 45-80 when playing as a moneyline underdog with odds of +114 or longer (36%).
• The White Sox have played in 154 games with an over/under set, and have combined with opponents to go over the total 70 times (70-76-8).
• The White Sox have covered 56.5% of their games this season, going 87-67-0 ATS.

Nationals Player Leaders

• C.J. Abrams is batting .259 with 35 doubles, five triples, 18 home runs and 36 walks. He has an on-base percentage of .317 and a slugging percentage of .433.
• Among qualified batters in the majors, he ranks 71st in batting average, 98th in on-base percentage, and 73rd in slugging.
• Abrams will look for his third straight game with a hit in this contest. During his last five outings he is hitting .182 with two doubles, a home run and four RBIs.
• James Wood leads Washington with 150 hits and an OBP of .352, plus a team-best slugging percentage of .475. He's batting .256.
• Among all qualified, he ranks 82nd in batting average, 36th in on-base percentage and 36th in slugging percentage.
• Wood has picked up at least one hit in three straight games. During his last five outings he is batting .278 with a double, three home runs, three walks and three RBIs.
• Luis Garcia has collected 120 base hits, an OBP of .287 and a slugging percentage of .395 this season.
• Josh Bell is batting .235 with a .323 OBP and 62 RBI for Washington this season.

White Sox Player Leaders

• Miguel Vargas a has .314 on-base percentage to lead the White Sox. He's batting .232 while slugging .396.
• Including all qualified hitters in the big leagues, his batting average puts him 129th, his on-base percentage ranks 105th, and he is 106th in slugging.
• Vargas takes a six-game hitting streak into this game. In his last 10 outings he is hitting .265 with two doubles, a home run, four walks and five RBIs.
• Lenyn Sosa's 131 hits and .423 slugging percentage are both team-highs. He has a batting average of .259 with an on-base percentage of .288.
• Including all qualified hitters, his batting average puts him 71st, his on-base percentage ranks 135th, and he is 77th in slugging.
• Chase Meidroth has 15 doubles, five home runs and 45 walks while hitting .257.
• Colson Montgomery is batting .231 with eight doubles, a triple, 19 home runs and 24 walks.

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