Phillies vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:12 a.m.

The Philadelphia Phillies are among the MLB teams busy on Friday, up against the Minnesota Twins.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Phillies vs Twins Game Info

• Philadelphia Phillies (94-65) vs. Minnesota Twins (69-90)
• Date: Friday, September 26, 2025
• Time: 6:45 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and MNNT

Phillies vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-166) | MIN: (+140)
• Spread: PHI: -1.5 (+128) | MIN: +1.5 (-154)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Phillies vs Twins Probable Starting Pitchers

Probable Pitchers: Aaron Nola (Phillies) - 4-10, 6.46 ERA vs Joe Ryan (Twins) - 13-9, 3.47 ERA

This contest's pitching matchup is set, as the Phillies will send Aaron Nola (4-10) to the mound, while Joe Ryan (13-9) will take the ball for the Twins. When Nola starts, his team is 7-9-0 against the spread this season. When Nola starts a game and his team is the favorite on the moneyline, they have a record of 4-7. When Ryan starts, the Twins have gone 12-16-0 against the spread. The Twins have a 1-4 record in Ryan's five starts this season when they were the underdog on the moneyline.

Phillies vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (51%)

Phillies vs Twins Moneyline

• The moneyline numbers for Phillies vs. Twins reveal Philadelphia as the favorite (-166) and Minnesota as the underdog (+140) on the road.

Phillies vs Twins Spread

• The Twins are +1.5 on the spread (-154 to cover), and Philadelphia is +128 to cover the runline.

Phillies vs Twins Over/Under

• The over/under for Phillies-Twins on Sept. 26 is 8.5. The over is -120, and the under is -102.

Bet on Philadelphia Phillies vs. Minnesota Twins on FanDuel today!

Phillies vs Twins Betting Trends

• The Phillies have been favorites in 119 games this season and have come away with the win 77 times (64.7%) in those contests.
• Philadelphia has a record of 38-14 when favored by -166 or more this year.
• The Phillies and their opponents have hit the over in 65 of their 152 games with a total set by oddsmakers this season.
• The Phillies have posted a record of 78-74-0 against the spread this season.
• The Twins are 25-39 in games they were listed as the moneyline underdog (winning 39.1% of those games).
• Minnesota has a 6-11 record (winning just 35.3% of its games) when it has played as a moneyline underdog of +140 or longer.
• The Twins have had an over/under set by oddsmakers 154 times, and have combined with opponents to go over the total in 72 of those games (72-75-7).
• The Twins have put together a 74-80-0 record against the spread this season.

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.369) and total hits (145) this season. He's batting .245 batting average while slugging .573.
• Among qualifying hitters in MLB, he ranks 101st in batting average, 10th in on-base percentage, and fourth in slugging.
• Bryce Harper is hitting .263 with 32 doubles, 27 home runs and 68 walks, while slugging .493 with an on-base percentage of .357.
• He is 59th in batting average, 24th in on-base percentage and 20th in slugging in the majors.
• Harper heads into this game looking to extend his two-game hit streak. In his last five games he is batting .211 with three walks.
• Bryson Stott has 126 hits this season and has a slash line of .257/.330/.394.
• Stott has recorded at least one base hit in two games in a row. In his last five games he is hitting .333 with two doubles, a home run, two walks and an RBI.
• Nick Castellanos has been key for Philadelphia with 136 hits, an OBP of .296 plus a slugging percentage of .406.

Twins Player Leaders

• Byron Buxton has an on-base percentage of .328, a slugging percentage of .551, and has 127 hits, all club-bests for the Twins (while batting .265).
• Including all qualified hitters in MLB, his batting average places him 52nd, his on-base percentage is 78th, and he is fifth in slugging.
• Trevor Larnach is batting .251 with 23 doubles, a triple, 17 home runs and 53 walks. He's slugging .404 with an on-base percentage of .324.
• His batting average is 89th among all qualified players, his on-base percentage is 85th, and he is 98th in slugging.
• Brooks Lee has 15 doubles, a triple, 16 home runs and 30 walks while hitting .237.
• Ryan Jeffers has 24 doubles, nine home runs and 49 walks while hitting .259.

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