Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 5:11 a.m.

The MLB's Monday schedule includes the Minnesota Twins taking on the San Francisco Giants.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Twins vs Giants Game Info

• Minnesota Twins (73-83) vs. San Francisco Giants (64-92)
• Date: Monday, September 21, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-118) | SF: (+100)
• Spread: MIN: -1.5 (+128) | SF: +1.5 (-154)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 9-10, 4.74 ERA vs Blade Tidwell (Giants) - 1-2, 4.56 ERA

The Twins will give the ball to Zebby Matthews (9-10, 4.74 ERA), who is eyeing win No. 10 on the season, and the Giants will turn to Blade Tidwell (1-2, 4.56 ERA). Matthews' team is 13-8-0 against the spread in his starts this season. Matthews' team has a record of 4-4 this season when he starts and they are the favorite on the moneyline. When Tidwell starts, the Giants have gone 4-4-0 against the spread. The Giants have been the underdog on the moneyline in seven of Tidwell's starts this season, and they went 2-5 in those matchups.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.8%)

Twins vs Giants Moneyline

• Minnesota is the favorite, -118 on the moneyline, while San Francisco is a +100 underdog despite being at home.

Twins vs Giants Spread

• The Twins are at the Giants and are favored by 1.5 runs (+128 to cover) on the runline. San Francisco is -154 to cover.

Twins vs Giants Over/Under

• The Twins-Giants contest on Sept. 21 has been given an over/under of 8.5 runs. The over is set at +100 and the under at -122.

Bet on Minnesota Twins vs. San Francisco Giants on FanDuel today!

Twins vs Giants Betting Trends

• The Twins have been chosen as favorites in 56 games this year and have walked away with the win 30 times (53.6%) in those games.
• This year Minnesota has won 19 of 36 games when listed as at least -118 on the moneyline.
• Contests with the Twins have gone over the total set by sportsbooks in 86 of 152 chances this season.
• The Twins have posted a record of 81-71-0 against the spread this season.
• The Giants have won 36.4% of the games this season they were the moneyline underdog (39-68).
• San Francisco is 33-55 (winning only 37.5% of its games) when playing as a moneyline underdog of +100 or longer.
• The Giants have had an over/under set by bookmakers 153 times, and have combined with opponents to go over the total in 76 of those games (76-67-10).
• The Giants are 73-80-0 ATS this season.

Twins Player Leaders

• Brooks Lee leads Minnesota with a slugging percentage of .430, fueled by 50 extra-base hits. He has a .253 batting average and an on-base percentage of .301.
• Among qualified hitters in the majors, he ranks 74th in batting average, 116th in on-base percentage, and 64th in slugging.
• Lee has hit safely in five straight games. During his last five outings he is hitting .474 with a double, a walk and two RBIs.
• Josh Bell has hit 20 homers this season while driving in 91 runs. He's batting .258 this season and slugging .421 with an on-base percentage of .320.
• His batting average is 68th among qualified players, his on-base percentage 88th, and his slugging percentage 73rd.
• Bell brings a five-game streak with at least one hit into this contest. In his last five games he is hitting .364 with a walk and four RBIs.
• Luke Keaschall leads Minnesota with an OBP of .370 this season while batting .278 with 56 walks and 76 runs scored.
• Keaschall enters this game with five games in a row with at least one hit. In his last five games he is batting .409 with a double and two RBIs.
• Kody Clemens leads Minnesota in total hits (120) this season while batting .236 with 55 extra-base hits.

Giants Player Leaders

• Jung Hoo Lee has accumulated a slugging percentage of .404, a team-best for the Giants. He's batting .276 with an on-base percentage of .320.
• Including all the qualifying hitters in the majors, he ranks 32nd in batting average, 88th in on-base percentage and 85th in slugging percentage.
• Jung Hoo Lee takes a three-game hitting streak into this game. In his last five games he is batting .263 with two doubles, a home run, two walks and two RBIs.
• Bryce Eldridge is hitting .269 with 23 doubles, 17 home runs and 59 walks. He's slugging .461 with an on-base percentage of .364.
• Drew Gilbert is hitting .231 with 14 doubles, three triples, 10 home runs and 37 walks.
• Christian Koss has five doubles, four home runs and nine walks while hitting .228.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!