Tigers vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:11 a.m.

The Monday schedule in MLB includes a matchup between the Detroit Tigers and the Washington Nationals.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Nationals Game Info

• Detroit Tigers (73-83) vs. Washington Nationals (73-83)
• Date: Monday, September 21, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Nationals.TV

Tigers vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-156) | WSH: (+132)
• Spread: DET: -1.5 (+128) | WSH: +1.5 (-154)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Tigers vs Nationals Probable Starting Pitchers

Probable Pitchers: River Ryan (Tigers) - 0-0, 0.00 ERA vs DJ Herz (Nationals) - 0-0, 0.00 ERA

The Tigers will give the nod to River Ryan versus the Nationals and DJ Herz. Ryan did not pitch as the moneyline favorite in any games last season. Herz's team was never the underdog on the moneyline a season ago in games he pitched.

Tigers vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (58.8%)

Tigers vs Nationals Moneyline

• Washington is a +132 underdog on the moneyline, while Detroit is a -156 favorite at home.

Tigers vs Nationals Spread

• The Tigers are hosting the Nationals and are favored by 1.5 runs (+128 to cover) on the runline. Washington is -154 to cover.

Tigers vs Nationals Over/Under

• A combined run total of 8.5 has been set for Tigers-Nationals on Sept. 21, with the over at +100 and the under at -122.

Bet on Detroit Tigers vs. Washington Nationals on FanDuel today!

Tigers vs Nationals Betting Trends

• The Tigers have won in 42, or 54.5%, of the 77 contests they have been named as odds-on favorites in this year.
• This year Detroit has won 13 of 18 games when listed as at least -156 on the moneyline.
• Contests with the Tigers have gone over the total set by sportsbooks in 66 of 150 chances this season.
• The Tigers are 77-73-0 against the spread in their 150 games that had a posted line this season.
• The Nationals have won 49 of the 116 games they were the underdog on the moneyline this season (42.2%).
• Washington has a 17-36 record (winning only 32.1% of its games) when it has played as a moneyline underdog of +132 or longer.
• The Nationals have had an over/under set by bookmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-66-6).
• The Nationals have gone 83-69-0 against the spread this season.

Tigers Player Leaders

• Kevin McGonigle leads Detroit with an OBP of .376, plus a team-best slugging percentage of .424. He's batting .274 on the season.
• Among the qualified hitters in MLB, his batting average ranks 35th, his on-base percentage ranks 11th, and he is 67th in slugging.
• Riley Greene leads Detroit with 141 hits. He is batting .285 this season and has 54 extra-base hits. He's also slugging .484 with an on-base percentage of .372.
• He is 14th in batting average, 13th in on-base percentage and 24th in slugging in the major leagues.
• Greene has picked up at least one hit in 10 games in a row. During his last 10 games he is batting .400 with two doubles, a triple, two home runs, two walks and 10 RBIs.
• Dillon Dingler is batting .243 with a .450 slugging percentage and 89 RBI this year.
• Dingler takes a three-game hitting streak into this game. During his last five outings he is hitting .211 with a double and two RBIs.
• Spencer Torkelson has been key for Detroit with 117 hits, an OBP of .326 plus a slugging percentage of .424.

Nationals Player Leaders

• C.J. Abrams has racked up a slugging percentage of .492, a team-high for the Nationals. He's batting .261 with an on-base percentage of .336.
• Including all the qualified hitters in MLB, his batting average ranks 61st, his on-base percentage ranks 61st, and he is 17th in slugging.
• James Wood's 130 hits and .390 OBP both pace his team. He has a batting average of .265 while slugging .513.
• He is 51st in batting average, fourth in on-base percentage and 11th in slugging percentage in MLB.
• Daylen Lile has put up a slugging percentage of .440, a team-high for the Nationals.
• Jacob Young has 21 doubles, three triples, 10 home runs and 33 walks while batting .249.

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