Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:11 a.m.

The Baltimore Orioles will take on the Toronto Blue Jays in MLB action on Monday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (75-81) vs. Toronto Blue Jays (77-79)
• Date: Monday, September 21, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-112) | TOR: (-104)
• Spread: BAL: +1.5 (-205) | TOR: -1.5 (+168)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 6-15, 4.11 ERA vs Trey Yesavage (Blue Jays) - 5-5, 3.65 ERA

The Orioles will give the nod to Shane Baz (6-15, 4.11 ERA), who is eyeing win No. 7 on the season, and the Blue Jays will counter with Trey Yesavage (5-5, 3.65 ERA). Baz's team is 14-15-0 against the spread this season in his starts. Baz's team is 5-6 this season when he starts and they are the moneyline favorite. The Blue Jays have a 5-12-0 ATS record in Yesavage's 17 starts with a set spread. The Blue Jays have a 1-6 record in Yesavage's seven starts this season when they were the underdog on the moneyline.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (54.5%)

Orioles vs Blue Jays Moneyline

• Looking at the moneyline for Orioles-Blue Jays, Baltimore is the favorite at -112, and Toronto is -104 playing on the road.

Orioles vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Orioles. The Blue Jays are +168 to cover, while the Orioles are -205 to cover as a 1.5-run underdog on the runline.

Orioles vs Blue Jays Over/Under

• A total of 7.5 runs has been set for the Orioles-Blue Jays contest on Sept. 21, with the over available at -112 and the under at -108.

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Orioles vs Blue Jays Betting Trends

• The Orioles have been chosen as favorites in 68 games this year and have walked away with the win 36 times (52.9%) in those games.
• This season Baltimore has been victorious 34 times in 64 chances when named as a favorite of at least -112 on the moneyline.
• Contests with the Orioles have gone over the total set by bookmakers in 79 of 155 chances this season.
• The Orioles have posted a record of 81-74-0 against the spread this season.
• The Blue Jays have a 30-39 record in games they were listed as the moneyline underdog (winning 43.5% of those games).
• Toronto is 26-35 (winning 42.6% of its games) when playing as a moneyline underdog of -104 or longer.
• The Blue Jays have played in 152 games with a set over/under, and have combined with opponents to go over the total 80 times (80-70-2).
• The Blue Jays have put together a 74-78-0 record ATS this season (covering 48.7% of the time).

Orioles Player Leaders

• Pete Alonso leads Baltimore in OBP (.358), slugging percentage (.500) and total hits (154) this season. He has a .264 batting average.
• He ranks 54th in batting average, 32nd in on-base percentage, and 14th in slugging among qualified hitters in MLB.
• Gunnar Henderson is hitting .223 with 27 doubles, five triples, 23 home runs and 65 walks, while slugging .397 with an on-base percentage of .308.
• He is 119th in batting average, 106th in on-base percentage and 91st in slugging in the major leagues.
• Coby Mayo has collected 90 base hits, an OBP of .298 and a slugging percentage of .471 this season.
• Leody Taveras has eight home runs, 54 RBI and a batting average of .216 this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has accumulated an on-base percentage of .336, a team-best for the Blue Jays. He's batting .263 and slugging .359.
• Including all qualified hitters in MLB, he ranks 56th in batting average, 61st in on-base percentage and 123rd in slugging percentage.
• Guerrero takes a four-game hitting streak into this matchup. In his last five games he is hitting .267 with three walks.
• Kazuma Okamoto paces his team with 129 hits. He has a batting average of .235 while slugging .459 with an on-base percentage of .310.
• Including all qualifying hitters, his batting average places him 105th, his on-base percentage ranks 104th, and he is 37th in slugging.
• Ernie Clement has put up a team-high .372 slugging percentage.
• George Springer is hitting .248 with 22 doubles, two triples, 15 home runs and 47 walks.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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