Sabres vs Flyers NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The Buffalo Sabres versus the Philadelphia Flyers is on the NHL schedule for Wednesday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Sabres vs Flyers Game Info

• Buffalo Sabres (4-3-2) vs. Philadelphia Flyers (2-6-3)
• Date: Wednesday, October 21, 2026
• Time: 7:30 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: TNT

Sabres vs Flyers Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Sabres vs Flyers Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Sabres win (59.7%)

Sabres vs Flyers Puck Line

• The Flyers are 1.5-goal underdogs against the Sabres. The Flyers are -152 to cover the spread, and the Sabres are +124.

Sabres vs Flyers Over/Under

• An over/under of 5.5 has been set for Sabres-Flyers on Oct. 21, with the over being -138 and the under +112.

Sabres vs Flyers Moneyline

• Looking at the moneyline for Sabres-Flyers, Buffalo is the favorite at -184, and Philadelphia is +152 playing on the road.

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