Senators vs Panthers NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The NHL's Wednesday slate includes the Ottawa Senators taking on the Florida Panthers.

Before you place your bet on this game at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Senators vs Panthers Game Info

• Ottawa Senators (6-3) vs. Florida Panthers (5-2-2)
• Date: Wednesday, October 21, 2026
• Time: 7:30 p.m. ET
• Venue: Canadian Tire Centre -- Ottawa, Ontario
• Coverage: ESPN+

Senators vs Panthers Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Senators vs Panthers Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Senators win (60.4%)

Senators vs Panthers Puck Line

• The Panthers are underdogs by 1.5 goals on the road against the Senators. The Panthers are -265 to cover the spread, and the Senators are +210.

Senators vs Panthers Over/Under

• The over/under for Senators-Panthers on Oct. 21 is 5.5. The over is -124, and the under is +102.

Senators vs Panthers Moneyline

• Ottawa is a -110 favorite on the moneyline, while Florida is a -110 underdog on the road.

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