Red Sox vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 5:14 a.m.

The Boston Red Sox will take on the Tampa Bay Rays in MLB action on Sunday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Red Sox vs Rays Game Info

• Boston Red Sox (85-70) vs. Tampa Bay Rays (75-80)
• Date: Sunday, September 21, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and NESN

Red Sox vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-120) | TB: (+102)
• Spread: BOS: -1.5 (+146) | TB: +1.5 (-176)
• Total: 8 -- Over: (-110) | Under: (-110)

Red Sox vs Rays Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 1-0, 0.87 ERA vs Joe Boyle (Rays) - 1-3, 4.64 ERA

The probable starters are Connelly Early (1-0) for the Red Sox and Joe Boyle (1-3) for the Rays. Early has a record of 1-1-0 ATS in two starts with a spread this season. Early's team lost his only start as a favorite this season. The Rays have a 2-5-0 ATS record in Boyle's seven starts that had a set spread. The Rays are 2-5 in Boyle's seven starts this season that they were the underdog on the moneyline.

Red Sox vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (52.7%)

Red Sox vs Rays Moneyline

• The moneyline numbers for Red Sox vs. Rays reveal Boston as the favorite (-120) and Tampa Bay as the underdog (+102) despite being the home team.

Red Sox vs Rays Spread

• The Rays are +1.5 on the spread (-176 to cover), and Boston is +146 to cover the runline.

Red Sox vs Rays Over/Under

• The over/under for the Red Sox versus Rays contest on Sept. 21 has been set at 8, with -110 odds on the over and -110 odds on the under.

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Red Sox vs Rays Betting Trends

• The Red Sox have won in 56, or 57.7%, of the 97 contests they have been named as odds-on favorites in this year.
• Boston has a record of 40-30 in contests when oddsmakers favor them by -120 or more on the moneyline.
• The Red Sox and their opponents have gone over in 72 of their 154 games with a total set by sportsbooks this season.
• In 154 games with a line this season, the Red Sox have a mark of 82-72-0 against the spread.
• The Rays have won 41.1% of the games this season they were the moneyline underdog (30-43).
• When it has played as a moneyline underdog with odds of +102 or longer, Tampa Bay has gone 22-27 (44.9%).
• The Rays have had an over/under set by oddsmakers 150 times, and have combined with opponents to go over the total in 66 of those games (66-76-8).
• The Rays have covered 44% of their games this season, going 66-84-0 against the spread.

Red Sox Player Leaders

• Jarren Duran leads Boston in OBP (.336), slugging percentage (.450) and total hits (155) this season. He has a .261 batting average.
• Among qualified hitters in baseball, his batting average ranks 61st, his on-base percentage ranks 56th, and he is 57th in slugging.
• Duran will look for his third straight game with a hit in this contest. In his last five games he is hitting .333 with a home run, three walks and two RBIs.
• Trevor Story has an OPS of .753, fueled by an OBP of .312 and a team-best slugging percentage of .441 this season. He's batting .265.
• Among all qualifying players, he is 50th in batting average, 106th in on-base percentage and 62nd in slugging percentage.
• Alex Bregman has 114 hits this season and has a slash line of .275/.359/.470.
• Bregman takes a three-game hitting streak into this game. During his last five outings he is batting .211 with a home run, four walks and two RBIs.
• Ceddanne Rafaela has been key for Boston with 127 hits, an OBP of .289 plus a slugging percentage of .405.
• Rafaela has safely hit in two games in a row. In his last five games he is batting .368 with a double, a walk and an RBI.

Rays Player Leaders

• Junior Caminero has 149 hits, a team-best for the Rays. He's batting .258 and slugging .535 with an on-base percentage of .301.
• Including all the qualified hitters in the majors, his batting average ranks 70th, his on-base percentage is 121st, and he is eighth in slugging.
• Yandy Diaz's .367 on-base percentage and .489 slugging percentage are both team-highs. He has a batting average of .302.
• His batting average is seventh among all qualified players, his on-base percentage ranks 13th, and he is 23rd in slugging.
• Brandon Lowe has 18 doubles, 29 home runs and 36 walks while batting .258.
• Chandler Simpson has 14 doubles, three triples and 20 walks while batting .297.

Red Sox vs Rays Head to Head

• 9/20/2025: 6-3 BOS (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/13/2025: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/12/2025: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/11/2025: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/11/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 10-8 TB (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/16/2025: 1-0 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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