Phillies vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 2:11 a.m.

The Philadelphia Phillies are among the MLB teams playing on Sunday, versus the Arizona Diamondbacks.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Phillies vs Diamondbacks Game Info

• Philadelphia Phillies (92-63) vs. Arizona Diamondbacks (78-77)
• Date: Sunday, September 21, 2025
• Time: 4:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-PH

Phillies vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-134) | ARI: (+114)
• Spread: PHI: -1.5 (+114) | ARI: +1.5 (-137)
• Total: 9 -- Over: (-110) | Under: (-110)

Phillies vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Phillies) - 12-6, 2.84 ERA vs Eduardo Rodríguez (Diamondbacks) - 8-8, 5.12 ERA

The probable starters are Ranger Suarez (12-6) for the Phillies and Eduardo Rodriguez (8-8) for the Diamondbacks. When Suarez starts, his team is 12-10-0 against the spread this season. Suarez's team has won 66.7% of his starts when they are favored on the moneyline (12-6). The Diamondbacks have a 10-16-0 record against the spread in Rodríguez's starts. The Diamondbacks have been the underdog on the moneyline in 11 of Rodríguez's starts this season, and they went 6-5 in those matchups.

Phillies vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (59.8%)

Phillies vs Diamondbacks Moneyline

• Arizona is the underdog, +114 on the moneyline, while Philadelphia is a -134 favorite despite being on the road.

Phillies vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-137 to cover), and Philadelphia is +114 to cover the runline.

Phillies vs Diamondbacks Over/Under

• A total of 9 runs has been set for the Phillies-Diamondbacks game on Sept. 21, with the over available at -110 and the under at -110.

Bet on Philadelphia Phillies vs. Arizona Diamondbacks on FanDuel today!

Phillies vs Diamondbacks Betting Trends

• The Phillies have been favorites in 115 games this season and have come away with the win 75 times (65.2%) in those contests.
• This season Philadelphia has been victorious 60 times in 88 chances when named as a favorite of at least -134 on the moneyline.
• Contests with the Phillies have gone over the total set by oddsmakers in 62 of 148 chances this season.
• The Phillies are 77-71-0 against the spread in their 148 games that had a posted line this season.
• The Diamondbacks have won 49.2% of the games this season they were the underdog on the moneyline (31-32).
• Arizona has gone 17-15 when playing as a moneyline underdog with odds of +114 or longer (53.1%).
• The Diamondbacks have combined with opponents to go over the total 75 times this season for a 75-69-7 record against the over/under.
• The Diamondbacks are 75-76-0 ATS this season.

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.369) and total hits (140) this season. He's batting .243 batting average while slugging .564.
• Among qualifying batters in MLB, he ranks 103rd in batting average, 12th in on-base percentage, and fourth in slugging.
• Bryce Harper is batting .263 with 32 doubles, 27 home runs and 68 walks, while slugging .498 with an on-base percentage of .360.
• He is 56th in batting average, 20th in on-base percentage and 17th in slugging among qualified batters.
• Bryson Stott is batting .257 with a .389 slugging percentage and 65 RBI this year.
• Nick Castellanos has 17 home runs, 69 RBI and a batting average of .255 this season.
• Castellanos takes a two-game hitting streak into this game. During his last five outings he is hitting .231 with a home run, a walk and four RBIs.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up a .391 on-base percentage and a .462 slugging percentage, both team-high averages for the Diamondbacks. He's batting .289.
• He is 13th in batting average, fifth in on-base percentage and 46th in slugging percentage among all qualifying hitters in the majors.
• Perdomo brings a 10-game hitting streak into this matchup. In his last 10 games he is batting .412 with four doubles, a triple, two home runs, nine walks and six RBIs.
• Corbin Carroll leads his team with 141 hits. He has a batting average of .258 while slugging .540 with an on-base percentage of .339.
• Including all qualified players, his batting average places him 70th, his on-base percentage ranks 52nd, and he is sixth in slugging.
• Ketel Marte is batting .279 with 25 doubles, 26 home runs and 63 walks.
• Gabriel Moreno is batting .285 with 12 doubles, a triple, nine home runs and 25 walks.

Phillies vs Diamondbacks Head to Head

• 9/20/2025: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 8-2 PHI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/4/2025: 11-9 ARI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/3/2025: 7-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/2/2025: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 12-5 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/10/2024: 11-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 3-2 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/8/2024: 6-4 PHI (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/23/2024: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!