Pirates vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 2:12 a.m.

The Pittsburgh Pirates will face the Athletics in MLB action on Sunday.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Athletics Game Info

• Pittsburgh Pirates (66-89) vs. Athletics (73-82)
• Date: Sunday, September 21, 2025
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-CA

Pirates vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-112) | OAK: (-104)
• Spread: PIT: +1.5 (-192) | OAK: -1.5 (+158)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Pirates vs Athletics Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Pirates) - 2-4, 4.10 ERA vs Mitch Spence (Athletics) - 3-5, 4.48 ERA

This contest's pitching matchup is set, as the Pirates will send Mike Burrows (2-4) to the mound, while Mitch Spence (3-5) will get the nod for the Athletics. Burrows' team is 9-8-0 against the spread in his starts this season. Burrows' team has a record of 1-3 this season when he starts and they are the favorite on the moneyline. The Athletics are 4-3-0 against the spread when Spence starts. The Athletics have been the underdog on the moneyline in seven of Spence's starts this season, and they went 2-5 in those games.

Pirates vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51%)

Pirates vs Athletics Moneyline

• The Pirates vs Athletics moneyline has the Pirates as a -112 favorite, while the Athletics are a -104 underdog on the road.

Pirates vs Athletics Spread

• The Pirates are hosting the Athletics and are 1.5 on the runline and -192 to cover, while Sacramento is +158 to cover the spread.

Pirates vs Athletics Over/Under

• The over/under for the Pirates versus Athletics game on Sept. 21 has been set at 8.5, with -114 odds on the over and -106 odds on the under.

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Pirates vs Athletics Betting Trends

• The Pirates have been victorious in 20, or 50%, of the 40 contests they have been chosen as favorites in this season.
• This year, the Pirates have won 20 of 38 games when listed as at least -112 or better on the moneyline.
• The Pirates and their opponents have hit the over in 56 of their 147 games with a total this season.
• The Pirates have an against the spread mark of 79-68-0 in 147 games with a line this season.
• The Athletics have won 46.5% of the games this season they were the underdog on the moneyline (53-61).
• The Athletics have a record of 50-59 when playing as a moneyline underdog with odds of -104 or longer (45.9%).
• The Athletics have combined with their opponents to go over the total 74 times this season for a 74-73-7 record against the over/under.
• The Athletics have an 82-72-0 record ATS this season (covering 53.2% of the time).

Pirates Player Leaders

• Bryan Reynolds has 137 hits to go with a slugging percentage of .403, both of which are tops among Pittsburgh hitters this season. He has a .243 batting average and an on-base percentage of .315.
• Among qualified hitters in the majors, he ranks 103rd in batting average, 102nd in on-base percentage, and 96th in slugging.
• Reynolds will look for his third straight game with a hit in this contest. In his last five games he is batting .222 with a double, a home run, three walks and two RBIs.
• Andrew McCutchen leads Pittsburgh in OBP (.335) this season, fueled by 110 hits. He's batting .240 while slugging .373.
• He ranks 110th in batting average, 59th in on-base percentage and 127th in slugging among qualified hitters.
• Oneil Cruz has collected 92 base hits, an OBP of .304 and a slugging percentage of .381 this season.
• Spencer Horwitz has nine home runs, 43 RBI and a batting average of .259 this season.

Athletics Player Leaders

• Brent Rooker has put up a team-high .488 slugging percentage. He's batting .264 with an on-base percentage of .335.
• Including all the qualified hitters in MLB, his batting average is 54th, his on-base percentage is 59th, and he is 25th in slugging.
• Tyler Soderstrom is hitting .276 with 31 doubles, a triple, 24 home runs and 53 walks. He's slugging .470 with an on-base percentage of .346.
• Including all qualifying hitters, he is 31st in batting average, 44th in on-base percentage and 42nd in slugging percentage.
• Nick Kurtz has 25 doubles, two triples, 33 home runs and 60 walks while batting .291.
• Jacob Wilson has a .359 OBP to lead his team.

Pirates vs Athletics Head to Head

• 9/20/2025: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/19/2025: 4-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/1/2024: 4-0 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/30/2024: 5-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/29/2024: 5-1 OAK (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/7/2023: 9-5 OAK (Favorite: Pirates, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/6/2023: 11-2 OAK (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 6/5/2023: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)

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