Rams vs 49ers Prediction, Odds, Picks, Best Bets for NFL Week 1 Thursday Night Football

The Los Angeles Rams versus the San Francisco 49ers is on the NFL schedule for Thursday.

Get the latest NFL odds ahead of this game on FanDuel Sportsbook.

Rams vs 49ers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Rams win (62.5%)

Rams vs 49ers Point Spread

The Rams are 3.5-point favorites against the 49ers. The Rams are -115 to cover the spread, while the 49ers are -105 to cover as a 3.5-point underdog.

Rams vs 49ers Over/Under

A total of 48.5 points has been set for the Rams-49ers matchup on Sept. 10, with the over available at -105 and the under at -115.

Rams vs 49ers Moneyline

The Rams vs 49ers moneyline has Los Angeles as a -198 favorite, while San Francisco is a +166 underdog on the road.

Rams vs 49ers Betting Trends

• The Rams were 12-5-0 against the spread last year.
• Against the spread, as 3.5-point favorites or more, the Rams went 9-3 last season.
• Out of 17 Los Angeles games last season, 10 went over the total.
• Against the spread, the 49ers were 11-6-0 last year.
• As a 3.5-point underdog or more, San Francisco had one win ATS (1-2) last year.
• In 17 49ers games last season, 10 of them went over the total.

Check out even more in-depth Rams vs. 49ers analysis on FanDuel Research.

Rams vs 49ers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAR: (-198) | SF: (+166)
• Spread: LAR: -3.5 (-115) | SF: +3.5 (-105)
• Total: 48.5 -- Over: (-105) | Under: (-115)

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