Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 10:12 p.m.

The MLB's Sunday schedule includes the New York Yankees facing the San Diego Padres.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Padres Game Info

• New York Yankees (80-61) vs. San Diego Padres (74-67)
• Date: Sunday, September 6, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and YES

Yankees vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-116) | SD: (-102)
• Spread: NYY: -1.5 (+146) | SD: +1.5 (-178)
• Total: 7 -- Over: (-110) | Under: (-110)

Yankees vs Padres Probable Starting Pitchers

Probable Pitchers: Gerrit Cole (Yankees) - 8-7, 3.29 ERA vs Michael King (Padres) - 9-9, 3.11 ERA

The Yankees will call on Gerrit Cole (8-7) against the Padres and Michael King (9-9). When Cole starts, his team is 7-11-0 against the spread this season. Cole's team has won 53.3% of his starts when they are favored on the moneyline (8-7). The Padres have a 10-18-0 record against the spread in King's starts. The Padres have a 4-6 record in King's 10 starts this season when they were the moneyline underdog.

Yankees vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (51.6%)

Yankees vs Padres Moneyline

• The moneyline numbers for Yankees vs. Padres reveal New York as the favorite (-116) and San Diego as the underdog (-102) despite being the home team.

Yankees vs Padres Spread

• The Yankees are 1.5-run road favorites on the runline against the Padres. The Yankees are +146 to cover, and the Padres are -178.

Yankees vs Padres Over/Under

• A total of 7 runs has been set for the Yankees-Padres game on Sept. 6, with the over available at -110 and the under at -110.

Bet on New York Yankees vs. San Diego Padres on FanDuel today!

Yankees vs Padres Betting Trends

• The Yankees have been chosen as favorites in 109 games this year and have walked away with the win 64 times (58.7%) in those games.
• This season New York has come away with a win 60 times in 103 chances when named as a favorite of at least -116 on the moneyline.
• The Yankees and their opponents have gone over the total this season in 60 of their 136 opportunities.
• The Yankees are 68-68-0 against the spread in their 136 games with a line set by sportsbooks this season.
• The Padres have won 47.9% of the games this season they were the underdog on the moneyline (35-38).
• When playing as a moneyline underdog with odds of -102 or longer, San Diego has a record of 30-38 (44.1%).
• The Padres have had an over/under set by bookmakers 141 times, and have combined with opponents to go over the total in 62 of those games (62-77-2).
• The Padres have put together an 82-59-0 record ATS this season.

Yankees Player Leaders

• Ben Rice leads New York with an OBP of .349, plus a team-best slugging percentage of .526. He's batting .257 on the season.
• He ranks 67th in batting average, 41st in on-base percentage, and seventh in slugging among qualifying hitters in baseball.
• Rice hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .348 with a home run and five RBIs.
• Luis Garcia leads New York in slugging percentage (.545) and total hits (130) this season. He's batting .284 with an on-base percentage of .317.
• Among qualifying hitters, his batting average ranks him 15th, his on-base percentage 93rd, and his slugging percentage third.
• Cody Bellinger is batting .265 with a .416 slugging percentage and 60 RBI this year.
• Jazz Chisholm has 19 home runs, 55 RBI and a batting average of .229 this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated a team-best OBP (.348) and slugging percentage (.446), while leading the Padres in hits (154, while batting .282).
• Including all qualifying hitters in the majors, he ranks 18th in batting average, 43rd in on-base percentage and 48th in slugging percentage.
• Manny Machado is batting .220 with 21 doubles, 24 home runs and 66 walks. He's slugging .402 with an on-base percentage of .306.
• He is 127th in batting average, 113th in on-base percentage and 89th in slugging percentage in the big leagues.
• Jackson Merrill is hitting .240 with 22 doubles, three triples, 22 home runs and 37 walks.
• Ty France is batting .295 with 19 doubles, two triples, 20 home runs and 32 walks.

Yankees vs Padres Head to Head

• 9/4/2026: 3-2 SD (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2025: 4-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/6/2025: 12-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/5/2025: 4-3 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2024: 5-2 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2024: 4-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2024: 8-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/28/2023: 10-7 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/26/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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