Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 1:12 p.m.

On Sunday in MLB, the Houston Astros are up against the Arizona Diamondbacks.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Diamondbacks Game Info

• Houston Astros (73-70) vs. Arizona Diamondbacks (75-68)
• Date: Sunday, September 6, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Dbacks.TV

Astros vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-110) | ARI: (-106)
• Spread: HOU: +1.5 (-188) | ARI: -1.5 (+155)
• Total: 8 -- Over: (-114) | Under: (-106)

Astros vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-7, 3.66 ERA vs Eduardo Rodríguez (Diamondbacks) - 14-5, 2.59 ERA

The Astros will give the ball to Peter Lambert (8-7, 3.66 ERA), who is eyeing win No. 9 on the season, and the Diamondbacks will counter with Eduardo Rodriguez (14-5, 2.59 ERA). Lambert's team is 14-10-0 against the spread in his starts this season. Lambert's team is 7-4 this season when he starts and they are the moneyline favorite. The Diamondbacks have an 18-10-0 ATS record in Rodríguez's 28 starts that had a set spread. The Diamondbacks have been the underdog on the moneyline in 16 of Rodríguez's starts this season, and they went 12-4 in those matchups.

Astros vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.3%)

Astros vs Diamondbacks Moneyline

• Arizona is a -106 underdog on the moneyline, while Houston is a -110 favorite at home.

Astros vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Astros. The Diamondbacks are +155 to cover, while the Astros are -188 to cover as a 1.5-run underdog on the runline.

Astros vs Diamondbacks Over/Under

• An over/under of 8 has been set for Astros-Diamondbacks on Sept. 6, with the over being -114 and the under -106.

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Astros vs Diamondbacks Betting Trends

• The Astros have won in 33, or 53.2%, of the 62 contests they have been named as odds-on favorites in this year.
• This season Houston has been victorious 32 times in 61 chances when named as a favorite of at least -110 on the moneyline.
• The Astros and their opponents have gone over in 72 of their 143 games with a total set by sportsbooks this season.
• The Astros are 71-72-0 against the spread in their 143 games with a line set by sportsbooks this season.
• The Diamondbacks have won 45.6% of the games this season they were the moneyline underdog (36-43).
• When playing as a moneyline underdog with odds of -106 or longer, Arizona has gone 35-44 (44.3%).
• In the 142 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 61 times (61-77-4).
• The Diamondbacks have a 76-66-0 record ATS this season.

Astros Player Leaders

• Yordan Alvarez has 159 hits and an OBP of .434 to go with a slugging percentage of .597. All three of those stats are tops among Houston hitters this season. He has a .315 batting average, as well.
• Among all qualified batters in baseball, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes has 25 doubles, a triple, 18 home runs and 61 walks. He's batting .259 and slugging .423 with an on-base percentage of .358.
• He is 64th in batting average, 30th in on-base percentage and 67th in slugging among qualified batters.
• Paredes takes a six-game streak with at least one hit into this matchup. During his last 10 outings he is hitting .257 with two doubles, a home run, seven walks and seven RBIs.
• Christian Walker has 115 hits this season and has a slash line of .227/.300/.422.
• Jeremy Pena has been key for Houston with 101 hits, an OBP of .327 plus a slugging percentage of .461.

Diamondbacks Player Leaders

• Corbin Carroll has accumulated a slugging percentage of .465, a team-best for the Diamondbacks. He's batting .238 with an on-base percentage of .334.
• Including all qualifying players, he is 103rd in batting average, while his on-base percentage ranks 65th and he is 35th in slugging.
• Geraldo Perdomo's .365 slugging percentage leads his team. He has a batting average of .250 with an on-base percentage of .357.
• Including all qualifying hitters, his batting average places him 78th, his on-base percentage is 31st, and he is 121st in slugging.
• Ketel Marte is batting .251 with 24 doubles, three triples, 22 home runs and 43 walks.
• Gabriel Moreno has collected 121 hits with a .380 OBP to pace his team in both.

Astros vs Diamondbacks Head to Head

• 9/5/2026: 4-3 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/4/2026: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/23/2025: 4-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/22/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/21/2025: 6-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2024: 12-6 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2024: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/6/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2023: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 9/30/2023: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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