Padres vs Yankees Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 4:12 a.m.

Saturday's slate in the MLB includes a matchup between the San Diego Padres and the New York Yankees.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Padres vs Yankees Game Info

• San Diego Padres (74-67) vs. New York Yankees (80-61)
• Date: Saturday, September 5, 2026
• Time: 7:15 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: FOX

Padres vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | NYY: (-102)
• Spread: SD: +1.5 (-194) | NYY: -1.5 (+160)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Padres vs Yankees Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Padres) - 11-7, 3.14 ERA vs Carlos Rodon (Yankees) - 4-3, 3.20 ERA

The Padres will give the nod to Robbie Ray (11-7) versus the Yankees and Carlos Rodon (4-3). Ray and his team are 15-9-0 ATS this season when he starts. Ray's team has won 63.6% of his starts when they are favored on the moneyline (7-4). When Rodon starts, the Yankees have gone 5-7-0 against the spread. The Yankees have a 1-2 record in Rodon's three starts this season when they were the moneyline underdog.

Padres vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (51.8%)

Padres vs Yankees Moneyline

• The Padres vs Yankees moneyline has San Diego as a -116 favorite, while New York is a -102 underdog on the road.

Padres vs Yankees Spread

• The Yankees are 1.5-run favorites against the spread for this matchup with the Padres. The Yankees are +160 to cover, while the Padres are -194 to cover as a 1.5-run underdog on the runline.

Padres vs Yankees Over/Under

• A total of 7.5 runs has been set for the Padres-Yankees contest on Sept. 5, with the over available at -124 and the under at +102.

Bet on San Diego Padres vs. New York Yankees on FanDuel today!

Padres vs Yankees Betting Trends

• The Padres have been favorites in 63 games this season and have come away with the win 35 times (55.6%) in those contests.
• This season San Diego has been victorious 32 times in 55 chances when named as a favorite of at least -116 on the moneyline.
• The Padres and their opponents have gone over the total this season in 62 of their 141 opportunities.
• The Padres have posted a record of 82-59-0 against the spread this season.
• The Yankees have put together a 13-12 record in games they were listed as the moneyline underdog (winning 52% of those games).
• New York has gone 13-8 when playing as a moneyline underdog with odds of -102 or longer (61.9%).
• The Yankees have had an over/under set by oddsmakers 136 times, and have combined with opponents to go over the total in 60 of those games (60-73-3).
• The Yankees have covered 50% of their games this season, going 68-68-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. has 154 hits and an OBP of .350 to go with a slugging percentage of .449. All three of those stats lead San Diego hitters this season. He has a .284 batting average, as well.
• Among qualifying hitters in MLB, his batting average ranks 17th, his on-base percentage ranks 40th, and he is 45th in slugging.
• Manny Machado is hitting .219 with 21 doubles, 24 home runs and 66 walks, while slugging .403 with an on-base percentage of .306.
• Among qualified batters, he is 126th in batting average, 112th in on-base percentage and 89th in slugging percentage.
• Jackson Merrill is batting .241 with a .418 slugging percentage and 70 RBI this year.
• Xander Bogaerts is batting .219 with a .321 OBP and 51 RBI for San Diego this season.
• Bogaerts brings a two-game hitting streak into this game. In his last five games he is hitting .267 with a double, four walks and four RBIs.

Yankees Player Leaders

• Ben Rice is batting .253 with 22 doubles, three triples, 35 home runs and 68 walks. He's slugging .518 with an on-base percentage of .347.
• He is 73rd in batting average, 42nd in on-base percentage and eighth in slugging percentage among all qualifying hitters in the big leagues.
• Rice brings a three-game hitting streak into this matchup. In his last five games he is hitting .217 with four RBIs.
• Luis Garcia paces his team with 129 hits and has a club-high .547 slugging percentage. He has a batting average of .285 with an on-base percentage of .318.
• He ranks 15th in batting average, 91st in on-base percentage and third in slugging percentage in the big leagues.
• Cody Bellinger a has .349 on-base percentage to lead the Yankees.
• Trent Grisham is batting .211 with 19 doubles, two triples, 18 home runs and 60 walks.

Padres vs Yankees Head to Head

• 9/4/2026: 3-2 SD (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2025: 4-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/6/2025: 12-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/5/2025: 4-3 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2024: 5-2 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2024: 4-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2024: 8-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/28/2023: 10-7 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/26/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!