Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 2:12 a.m.

The Houston Astros are among the MLB teams busy on Saturday, up against the Arizona Diamondbacks.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Diamondbacks Game Info

• Houston Astros (73-69) vs. Arizona Diamondbacks (74-68)
• Date: Saturday, September 5, 2026
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-130) | ARI: (+110)
• Spread: HOU: -1.5 (+162) | ARI: +1.5 (-196)
• Total: 8.5 -- Over: (-130) | Under: (+106)

Astros vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Ethan Pecko (Astros) - 1-0, 6.23 ERA vs Brandon Pfaadt (Diamondbacks) - 7-2, 3.49 ERA

The Astros will give the nod to Ethan Pecko (1-0, 6.23 ERA), who is eyeing win No. 2 on the season, and the Diamondbacks will turn to Brandon Pfaadt (7-2, 3.49 ERA). Pecko and his team have a record of 2-1-0 against the spread when he starts. Pecko's team won his only start as a favorite this season. The Diamondbacks have a 14-1-0 ATS record in Pfaadt's 15 starts that had a set spread. The Diamondbacks have been the moneyline underdog in 10 of Pfaadt's starts this season, and they went 7-3 in those games.

Astros vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.7%)

Astros vs Diamondbacks Moneyline

• The moneyline numbers for Astros vs. Diamondbacks reveal Houston as the favorite (-130) and Arizona as the underdog (+110) on the road.

Astros vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Astros. The Diamondbacks are -196 to cover the spread, and the Astros are +162.

Astros vs Diamondbacks Over/Under

• A combined run total of 8.5 has been set for Astros-Diamondbacks on Sept. 5, with the over at -130 and the under at +106.

Bet on Houston Astros vs. Arizona Diamondbacks on FanDuel today!

Astros vs Diamondbacks Betting Trends

• The Astros have been victorious in 33, or 53.2%, of the 62 contests they have been chosen as favorites in this season.
• This year Houston has won 17 of 36 games when listed as at least -130 on the moneyline.
• The Astros' games have gone over the total in 72 of their 142 opportunities.
• The Astros are 70-72-0 against the spread in their 142 games with a line set by sportsbooks this season.
• The Diamondbacks have won 36 of the 79 games they were listed as the moneyline underdog this season (45.6%).
• Arizona has a 23-27 record (winning 46% of its games) when playing as a moneyline underdog of +110 or longer.
• The Diamondbacks have played in 141 games with an over/under set, and have combined with their opponents to go over the total 61 times (61-76-4).
• The Diamondbacks have put together a 76-65-0 record against the spread this season (covering 53.9% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.433), slugging percentage (.602) and total hits (157) this season. He has a .316 batting average.
• Among qualifying hitters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is batting .257 with 24 doubles, a triple, 18 home runs and 61 walks, while slugging .422 with an on-base percentage of .357.
• He ranks 65th in batting average, 33rd in on-base percentage and 66th in slugging among qualified hitters.
• Paredes has picked up a hit in five straight games. During his last five outings he is hitting .222 with a double, a home run, three walks and two RBIs.
• Christian Walker is batting .228 with a .426 slugging percentage and 77 RBI this year.
• Walker takes a two-game hitting streak into this game. During his last five outings he is batting .188 with a walk and two RBIs.
• Jeremy Pena has been key for Houston with 100 hits, an OBP of .332 plus a slugging percentage of .469.

Diamondbacks Player Leaders

• Corbin Carroll is leading the Diamondbacks with 123 hits. He's batting .241 and slugging .470 with an on-base percentage of .337.
• Including all qualified hitters in the majors, he ranks 97th in batting average, 59th in on-base percentage and 32nd in slugging percentage.
• Geraldo Perdomo leads his team with a .369 slugging percentage. He has a batting average of .253 with an on-base percentage of .360.
• He is currently 73rd in batting average, 26th in on-base percentage and 119th in slugging percentage among all qualifying hitters.
• Ketel Marte is hitting .251 with 23 doubles, three triples, 21 home runs and 42 walks.
• Gabriel Moreno's .376 OBP paces his team.

Astros vs Diamondbacks Head to Head

• 9/4/2026: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/23/2025: 4-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/22/2025: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/21/2025: 6-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2024: 12-6 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2024: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/6/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2023: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 9/30/2023: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/29/2023: 2-1 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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