Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 6:12 a.m.

On Friday in MLB, the Seattle Mariners are up against the Los Angeles Angels.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Angels Game Info

• Seattle Mariners (79-68) vs. Los Angeles Angels (69-78)
• Date: Friday, September 12, 2025
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Apple TV+

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-164) | LAA: (+138)
• Spread: SEA: -1.5 (+126) | LAA: +1.5 (-152)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: Luis Castillo (Mariners) - 9-8, 3.85 ERA vs Yusei Kikuchi (Angels) - 6-11, 4.18 ERA

The Mariners will look to Luis Castillo (9-8) versus the Angels and Yusei Kikuchi (6-11). When Castillo starts, his team is 13-16-0 against the spread this season. Castillo's team has been victorious in 54.5% of the games he's started as the moneyline favorite with a record of 12-10. The Angels have a 16-14-0 ATS record in Kikuchi's 30 starts that had a set spread. The Angels have been the moneyline underdog in 18 of Kikuchi's starts this season, and they went 6-12 in those matchups.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (64.5%)

Mariners vs Angels Moneyline

• Looking at the moneyline for Mariners-Angels, Seattle is the favorite at -164, and Los Angeles is +138 playing on the road.

Mariners vs Angels Spread

• The Mariners are favored by 1.5 runs at home versus the Angels. The Mariners are +126 to cover the spread, while the Angels are -152.

Mariners vs Angels Over/Under

• A combined run total of 7.5 has been set for Mariners-Angels on Sept. 12, with the over at -122 and the under at -100.

Bet on Seattle Mariners vs. Los Angeles Angels on FanDuel today!

Mariners vs Angels Betting Trends

• The Mariners have been victorious in 57, or 57%, of the 100 contests they have been chosen as favorites in this season.
• This season Seattle has been victorious 22 times in 31 chances when named as a favorite of at least -164 on the moneyline.
• The Mariners and their opponents have gone over in 76 of their 142 games with a total set by sportsbooks this season.
• The Mariners have an against the spread record of 61-81-0 in 142 games with a line this season.
• The Angels have been the moneyline underdog 108 total times this season. They've gone 50-58 in those games.
• When playing as a moneyline underdog with odds of +138 or longer, Los Angeles has gone 22-21 (51.2%).
• In the 145 games oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 77 times (77-63-5).
• The Angels have a 79-66-0 record against the spread this season.

Mariners Player Leaders

• Cal Raleigh has 129 hits and an OBP of .354, both of which are tops among Seattle hitters this season. He has a .239 batting average and a slugging percentage of .570.
• Among all qualifying hitters, he ranks 119th in batting average, his on-base percentage ranks 33rd, and he is third in slugging.
• Julio Rodriguez has hit 30 homers this season while driving in 89 runs. He's batting .267 this season and slugging .474 with an on-base percentage of .317.
• He is 43rd in batting average, 101st in on-base percentage and 34th in slugging among qualified hitters.
• Rodriguez has picked up a hit in two straight games. During his last five outings he is batting .304 with three doubles, a walk and three RBIs.
• Josh Naylor is batting .283 with a .451 slugging percentage and 80 RBI this year.
• Eugenio Suarez is batting .231 with a .305 OBP and 109 RBI for Seattle this season.

Angels Player Leaders

• Taylor Ward has 31 doubles, two triples, 30 home runs and 72 walks while hitting .226. He's slugging .461 with an on-base percentage of .318.
• Including all the qualifying hitters in MLB, he is 140th in batting average, 99th in on-base percentage and 46th in slugging percentage.
• Ward hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .200 with a double, a walk and two RBIs.
• Zach Neto is slugging .474 to lead his team. He has a batting average of .257 with an on-base percentage of .319.
• His batting average ranks 81st among all qualified players, his on-base percentage is 97th, and he is 34th in slugging.
• Jo Adell has 114 hits, a team-best for the Angels.
• Mike Trout has a .368 OBP to pace his team.

Mariners vs Angels Head to Head

• 9/11/2025: 7-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/27/2025: 4-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 7/26/2025: 7-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/25/2025: 3-2 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/24/2025: 4-2 SEA (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/8/2025: 3-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/7/2025: 8-6 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/6/2025: 5-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/30/2025: 9-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/29/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!