Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 4:16 a.m.

The Milwaukee Brewers will take on the St. Louis Cardinals in MLB action on Friday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (89-58) vs. St. Louis Cardinals (72-75)
• Date: Friday, September 12, 2025
• Time: 8:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: FDSWI and FDSMW

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-184) | STL: (+154)
• Spread: MIL: -1.5 (+108) | STL: +1.5 (-128)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Quinn Priester (Brewers) - 12-2, 3.25 ERA vs Andre Pallante (Cardinals) - 6-13, 5.28 ERA

The Brewers will give the nod to Quinn Priester (12-2) versus the Cardinals and Andre Pallante (6-13). Priester's team is 13-8-0 against the spread in his starts this season. Priester's team has won 80% of his starts when they are favored on the moneyline (8-2). The Cardinals have a 14-14-0 record against the spread in Pallante's starts. The Cardinals have a 7-11 record in Pallante's 18 starts this season when they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (60.3%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the underdog at +154, and Milwaukee is -184 playing at home.

Brewers vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-128 to cover), and Milwaukee is +108 to cover the runline.

Brewers vs Cardinals Over/Under

• The over/under for Brewers-Cardinals on Sept. 12 is 8.5. The over is -102, and the under is -120.

Bet on Milwaukee Brewers vs. St. Louis Cardinals on FanDuel today!

Brewers vs Cardinals Betting Trends

• The Brewers have won in 53, or 64.6%, of the 82 contests they have been named as odds-on favorites in this year.
• This season Milwaukee has come away with a win 12 times in 14 chances when named as a favorite of at least -184 on the moneyline.
• The Brewers and their opponents have hit the over in 72 of their 144 games with a total set by oddsmakers this season.
• The Brewers are 81-63-0 against the spread in their 144 games that had a posted line this season.
• The Cardinals are 37-40 in games they were the underdog on the moneyline (winning 48.1% of those games).
• St. Louis has gone 2-8 in games it has played as a moneyline underdog with odds of +154 or longer (20%).
• The Cardinals have combined with opponents to hit the over on the total 72 times this season for a 72-64-5 record against the over/under.
• The Cardinals have covered 49.6% of their games this season, going 70-71-0 against the spread.

Brewers Player Leaders

• Brice Turang leads Milwaukee in slugging percentage (.445) thanks to 45 extra-base hits. He has a .289 batting average and an on-base percentage of .356.
• Among all qualifying hitters in baseball, he is 14th in batting average, 27th in on-base percentage, and 64th in slugging.
• William Contreras has 140 hits this season and a team-best OBP of .359. He's batting .263 and slugging .408.
• He ranks 62nd in batting average, 21st in on-base percentage and 94th in slugging among qualifying hitters.
• Christian Yelich is batting .267 with a .460 slugging percentage and 93 RBI this year.
• Jackson Chourio leads Milwaukee in total hits (135) this season while batting .278 with 57 extra-base hits.
• Chourio heads into this game on a four-game hitting streak. During his last five outings he is batting .273 with two doubles, two home runs, a walk and three RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up 125 hits with a .450 slugging percentage, both team-best stats for the Cardinals. He's batting .282 and with an on-base percentage of .331.
• He is 21st in batting average, 68th in on-base percentage and 59th in slugging percentage among all qualifying hitters in MLB.
• Willson Contreras is batting .253 with 30 doubles, a triple, 20 home runs and 42 walks. He's slugging .444 with an on-base percentage of .337.
• He is 89th in batting average, 55th in on-base percentage and 65th in slugging percentage in MLB.
• Masyn Winn has 27 doubles, nine home runs and 34 walks while hitting .253.
• Lars Nootbaar has 22 doubles, a triple, 13 home runs and 56 walks while batting .240.

Brewers vs Cardinals Head to Head

• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2025: 6-0 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/27/2025: 7-1 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2024: 7-4 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2024: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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