Twins vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:11 a.m.

MLB action on Friday includes the Minnesota Twins facing the Arizona Diamondbacks.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Diamondbacks Game Info

• Minnesota Twins (64-82) vs. Arizona Diamondbacks (73-74)
• Date: Friday, September 12, 2025
• Time: 8:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and ARID

Twins vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-132) | ARI: (+112)
• Spread: MIN: -1.5 (+152) | ARI: +1.5 (-184)
• Total: 8 -- Over: (-122) | Under: (-100)

Twins vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Pablo Lopez (Twins) - 5-4, 2.83 ERA vs Brandon Pfaadt (Diamondbacks) - 13-8, 5.18 ERA

The Twins will give the ball to Pablo Lopez (5-4, 2.83 ERA), who is eyeing win No. 6 on the season, and the Diamondbacks will counter with Brandon Pfaadt (13-8, 5.18 ERA). When Lopez starts, his team is 8-4-0 against the spread this season. Lopez's team is 7-2 this season when he starts and they are the moneyline favorite. The Diamondbacks are 18-11-0 ATS in Pfaadt's 29 starts with a set spread. The Diamondbacks have been the moneyline underdog in 14 of Pfaadt's starts this season, and they went 7-7 in those games.

Twins vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (53.7%)

Twins vs Diamondbacks Moneyline

• The Twins vs Diamondbacks moneyline has Minnesota as a -132 favorite, while Arizona is a +112 underdog on the road.

Twins vs Diamondbacks Spread

• The Diamondbacks are at +1.5 on the runline against the Twins. The Diamondbacks are -184 to cover the spread, and the Twins are +152.

Twins vs Diamondbacks Over/Under

• The Twins-Diamondbacks contest on Sept. 12 has been given an over/under of 8 runs. The over is set at -122 and the under at -100.

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Twins vs Diamondbacks Betting Trends

• The Twins have won in 39, or 47%, of the 83 contests they have been named as odds-on favorites in this year.
• This year Minnesota has won 21 of 42 games when listed as at least -132 on the moneyline.
• The Twins and their opponents have gone over the total this season in 67 of their 141 opportunities.
• In 141 games with a line this season, the Twins have a mark of 69-72-0 against the spread.
• The Diamondbacks have put together a 29-31 record in games they were the underdog on the moneyline (winning 48.3% of those games).
• Arizona is 17-15 (winning 53.1% of its games) when playing as a moneyline underdog of +112 or longer.
• In the 143 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 71 times (71-66-6).
• The Diamondbacks have put together a 70-73-0 record ATS this season (covering 49% of the time).

Twins Player Leaders

• Byron Buxton leads Minnesota with 117 hits and an OBP of .337 this season. He has a .275 batting average and a slugging percentage of .568.
• He ranks 33rd in batting average, 55th in on-base percentage, and fourth in slugging among all qualifying hitters in MLB.
• Buxton hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .313 with a triple, two home runs, a walk and four RBIs.
• Trevor Larnach leads Minnesota in slugging percentage (.409) thanks to 38 extra-base hits. He's batting .256 with an on-base percentage of .328.
• His batting average ranks 82nd among qualified players, his on-base percentage 77th, and his slugging percentage 89th.
• Brooks Lee has collected 104 base hits, an OBP of .288 and a slugging percentage of .371 this season.
• Royce Lewis has 12 home runs, 44 RBI and a batting average of .231 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has accumulated a team-high OBP (.383) and slugging percentage (.449). He's batting .284.
• Including all qualified players in the majors, he is 20th in batting average, sixth in on-base percentage and 61st in slugging percentage.
• Corbin Carroll's 131 hits pace his team. He has a batting average of .254 while slugging .547 with an on-base percentage of .332.
• Including all qualified hitters, he ranks 86th in batting average, 67th in on-base percentage and sixth in slugging percentage.
• Ketel Marte is hitting .281 with 22 doubles, 25 home runs and 63 walks.
• Gabriel Moreno is hitting .286 with 11 doubles, a triple, eight home runs and 19 walks.

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