Yankees vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 12

Odds updated as of 2:11 a.m.

The Friday slate in MLB includes a matchup between the New York Yankees and the Boston Red Sox.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Red Sox Game Info

• New York Yankees (81-65) vs. Boston Red Sox (81-66)
• Date: Friday, September 12, 2025
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: Apple TV+

Yankees vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-122) | BOS: (+104)
• Spread: NYY: -1.5 (+138) | BOS: +1.5 (-166)
• Total: 9 -- Over: (-100) | Under: (-122)

Yankees vs Red Sox Probable Starting Pitchers

Probable Pitchers: Luis Gil (Yankees) - 3-1, 3.31 ERA vs Lucas Giolito (Red Sox) - 10-3, 3.38 ERA

This contest's pitching matchup is set, as the Yankees will send Luis Gil (3-1) to the mound, while Lucas Giolito (10-3) will get the nod for the Red Sox. Gil's team is 3-4-0 against the spread in his starts this season. Gil's team is 4-3 this season when he starts and they are the moneyline favorite. When Giolito starts, the Red Sox are 16-7-0 against the spread. The Red Sox have a 7-4 record in Giolito's 11 starts this season when they were the underdog on the moneyline.

Yankees vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (52.5%)

Yankees vs Red Sox Moneyline

• Boston is the underdog, +104 on the moneyline, while New York is a -122 favorite despite being on the road.

Yankees vs Red Sox Spread

• The Red Sox are +1.5 on the spread (-166 to cover), and New York is +138 to cover the runline.

Yankees vs Red Sox Over/Under

• Yankees versus Red Sox, on Sept. 12, has an over/under of 9, with the over being -100 and the under -122.

Bet on New York Yankees vs. Boston Red Sox on FanDuel today!

Yankees vs Red Sox Betting Trends

• The Yankees have come away with 72 wins in the 123 contests they have been listed as the favorites in this season.
• New York has a record of 68-47 in contests when bookmakers favor them by -122 or more on the moneyline.
• The Yankees' games have gone over the total in 71 of their 144 opportunities.
• The Yankees have posted a record of 66-78-0 against the spread this season.
• The Red Sox are 22-25 in games they were the underdog on the moneyline (winning 46.8% of those games).
• Boston has gone 18-17 in games it has played as a moneyline underdog with odds of +104 or longer (51.4%).
• In the 146 games oddsmakers have set an over/under for the Red Sox, they have combined with opponents to go over the total 69 times (69-71-6).
• The Red Sox have put together a 79-67-0 record against the spread this season.

Yankees Player Leaders

• Aaron Judge leads New York with 158 hits and an OBP of .443, plus a team-best slugging percentage of .669. He's batting .322.
• Among qualified hitters, he is first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger is hitting .277 with 24 doubles, five triples, 28 home runs and 48 walks, while slugging .500 with an on-base percentage of .334.
• Among qualifying batters, he is 29th in batting average, 63rd in on-base percentage and 19th in slugging percentage.
• Bellinger has picked up at least one hit in four straight games. During his last five outings he is hitting .313 with a double, a home run, five walks and three RBIs.
• Trent Grisham has 107 hits this season and has a slash line of .242/.350/.471.
• Jazz Chisholm is batting .240 with a .336 OBP and 72 RBI for New York this season.

Red Sox Player Leaders

• Jarren Duran has accumulated a team-best OBP (.334) and slugging percentage (.444), while pacing the Red Sox in hits (146, while batting .258).
• Including all qualifying hitters, he ranks 80th in batting average, while his on-base percentage ranks 63rd and he is 65th in slugging.
• Duran brings a three-game hitting streak into this game. During his last five outings he is batting .273 with three doubles and two RBIs.
• Trevor Story is hitting .263 with 27 doubles, 24 home runs and 31 walks. He's slugging .443 with an on-base percentage of .310.
• Including all qualifying players, he ranks 62nd in batting average, 112th in on-base percentage and 67th in slugging percentage.
• Alex Bregman has 27 doubles, 16 home runs and 42 walks while batting .279.
• Ceddanne Rafaela is batting .241 with 29 doubles, three triples, 16 home runs and 23 walks.

Yankees vs Red Sox Head to Head

• 8/24/2025: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/23/2025: 12-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/22/2025: 1-0 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/21/2025: 6-3 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/15/2025: 2-0 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/14/2025: 4-3 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/13/2025: 2-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 11-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 6/7/2025: 10-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2025: 9-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)

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