Guardians vs Rangers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:12 a.m.

In MLB action on Friday, the Cleveland Guardians face the Texas Rangers.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Rangers Game Info

• Cleveland Guardians (86-73) vs. Texas Rangers (80-79)
• Date: Friday, September 26, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and Victory+

Guardians vs Rangers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-148) | TEX: (+126)
• Spread: CLE: -1.5 (+136) | TEX: +1.5 (-164)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Guardians vs Rangers Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 7-6, 4.15 ERA vs Jack Leiter (Rangers) - 9-10, 3.92 ERA

The Guardians will give the nod to Slade Cecconi (7-6, 4.15 ERA), who is eyeing win No. 8 on the season, and the Rangers will turn to Jack Leiter (9-10, 3.92 ERA). Cecconi's team is 13-8-0 against the spread this season in his starts. Cecconi's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 6-3. The Rangers are 16-12-0 ATS in Leiter's 28 starts that had a set spread. The Rangers have a 5-14 record in Leiter's 19 starts this season when they were the moneyline underdog.

Guardians vs Rangers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rangers win (51.2%)

Guardians vs Rangers Moneyline

• Looking at the moneyline for Guardians-Rangers, Cleveland is the favorite at -148, and Texas is +126 playing on the road.

Guardians vs Rangers Spread

• The Guardians are hosting the Rangers and are favored by 1.5 runs on the spread. The Guardians are +136 to cover the runline, with the Rangers being -164.

Guardians vs Rangers Over/Under

• The over/under for Guardians-Rangers on Sept. 26 is 7.5. The over is -122, and the under is -100.

Bet on Cleveland Guardians vs. Texas Rangers on FanDuel today!

Guardians vs Rangers Betting Trends

• The Guardians have been favorites in 66 games this season and have come away with the win 42 times (63.6%) in those contests.
• Cleveland has a record of 11-4 in contests when bookmakers favor them by -148 or more on the moneyline.
• The Guardians and their opponents have hit the over in 66 of their 155 games with a total set by oddsmakers this season.
• In 155 games with a line this season, the Guardians have a mark of 85-70-0 against the spread.
• The Rangers have put together a 30-46 record in games they were listed as the moneyline underdog (winning 39.5% of those games).
• In games it has played as a moneyline underdog with odds of +126 or longer, Texas has a 3-14 record (winning just 17.6% of its games).
• The Rangers have had an over/under set by bookmakers 158 times, and have combined with opponents to go over the total in 69 of those games (69-87-2).
• The Rangers have an 83-75-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 165 hits and an OBP of .361 this season. He has a .284 batting average and a slugging percentage of .508.
• Among all qualifying hitters in MLB, he is 21st in batting average, 20th in on-base percentage, and 14th in slugging.
• Ramirez will look for his ninth straight game with a hit in this matchup. During his last 10 games he is hitting .333 with five doubles, two home runs, seven walks and eight RBIs.
• Steven Kwan has hit 11 homers this season while driving in 56 runs. He's batting .275 this season and slugging .379 with an on-base percentage of .333.
• His batting average is 32nd among qualified players, his on-base percentage 65th, and his slugging percentage 125th.
• Kyle Manzardo is batting .232 with a .449 slugging percentage and 68 RBI this year.
• Angel Martinez is batting .226 with a .268 OBP and 45 RBI for Cleveland this season.

Rangers Player Leaders

• Josh Smith has accumulated a team-high .366 slugging percentage. He's batting .251 with an on-base percentage of .335.
• Including all the qualifying hitters in MLB, his batting average ranks 89th, his on-base percentage ranks 60th, and he is 136th in slugging.
• Adolis Garcia has 28 doubles, 18 home runs and 27 walks while hitting .226. He's slugging .391 with an on-base percentage of .270.
• Including all qualified players, he is 139th in batting average, 145th in on-base percentage and 116th in slugging percentage.
• Josh Jung is hitting .249 with 21 doubles, a triple, 14 home runs and 26 walks.
• Jake Burger has 15 doubles, a triple, 16 home runs and 12 walks while batting .236.

Guardians vs Rangers Head to Head

• 8/24/2025: 5-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/23/2025: 10-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/22/2025: 4-3 TEX (Favorite: Rangers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/25/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/24/2024: 13-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/23/2024: 5-3 TEX (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/15/2024: 4-0 TEX (Favorite: Rangers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/14/2024: 7-4 CLE (Favorite: Rangers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/13/2024: 7-0 CLE (Favorite: Rangers, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/17/2023: 9-2 CLE (Favorite: Rangers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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