Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 2:11 a.m.

On Sunday in MLB, the Los Angeles Dodgers are playing the San Francisco Giants.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (88-67) vs. San Francisco Giants (76-79)
• Date: Sunday, September 21, 2025
• Time: 4:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and NBCS-BA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-245) | SF: (+200)
• Spread: LAD: -1.5 (-120) | SF: +1.5 (-100)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Emmet Sheehan (Dodgers) - 6-3, 3.17 ERA vs Trevor McDonald (Giants) - 0-0, 9.00 ERA

The probable pitchers are Emmet Sheehan (6-3) for the Dodgers and Trevor McDonald for the Giants. Sheehan and his team are 5-5-0 ATS this season when he starts. Sheehan's team has a record of 5-4 this season when he starts and they are the favorite on the moneyline. McDonald and his team were underdogs on the moneyline each game he pitched a season ago.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (66.7%)

Dodgers vs Giants Moneyline

• San Francisco is the underdog, +200 on the moneyline, while Los Angeles is a -245 favorite at home.

Dodgers vs Giants Spread

• The Dodgers are hosting the Giants and are favored by 1.5 runs on the spread. The Dodgers are -120 to cover the runline, with the Giants being -100.

Dodgers vs Giants Over/Under

• A combined run total of 8.5 has been set for Dodgers-Giants on Sept. 21, with the over at -128 and the under at +104.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have been chosen as favorites in 136 games this year and have walked away with the win 78 times (57.4%) in those games.
• Los Angeles has a record of 21-6 in contests when oddsmakers favor them by -245 or more on the moneyline.
• Contests with the Dodgers have gone over the total set by sportsbooks in 74 of 153 chances this season.
• The Dodgers have posted a record of 66-87-0 against the spread this season.
• The Giants have won 42.9% of the games this season they were the underdog on the moneyline (27-36).
• San Francisco has not yet played a game with moneyline odds of +200 or longer.
• The Giants have combined with opponents to hit the over on the total 74 times this season for a 74-72-8 record against the over/under.
• The Giants have a 72-82-0 record against the spread this season.

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 166 hits and an OBP of .395, plus a team-best slugging percentage of .623. He's batting .283.
• Among qualified hitters, he ranks 19th in batting average, his on-base percentage ranks third, and he is second in slugging.
• Ohtani has picked up at least one hit in eight games in a row. During his last 10 games he is batting .333 with three doubles, five home runs, nine walks and eight RBIs.
• Mookie Betts has 23 doubles, two triples, 20 home runs and 60 walks. He's batting .260 and slugging .414 with an on-base percentage of .330.
• His batting average is 65th among qualified players, his on-base percentage 69th, and his slugging percentage 85th.
• Betts has picked up a hit in two straight games. In his last five games he is hitting .167 with a double, a home run, three walks and an RBI.
• Freddie Freeman has 157 hits this season and has a slash line of .292/.363/.490.
• Andy Pages is batting .278 with a .319 OBP and 82 RBI for Los Angeles this season.

Giants Player Leaders

• Rafael Devers has racked up a team-best OBP (.370), while pacing the Giants in hits (146). He's batting .251 and slugging.
• Including all qualifying hitters in the big leagues, his batting average puts him 89th, his on-base percentage ranks 11th, and he is 43rd in slugging.
• Jung Hoo Lee is batting .263 with 30 doubles, 11 triples, eight home runs and 47 walks. He's slugging .404 with an on-base percentage of .327.
• Including all qualifying players, he is 56th in batting average, 77th in on-base percentage and 95th in slugging percentage.
• Willy Adames is batting .227 with 21 doubles, two triples, 28 home runs and 78 walks.
• Matt Chapman is hitting .234 with 21 doubles, two triples, 21 home runs and 69 walks.

Dodgers vs Giants Head to Head

• 9/20/2025: 7-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/11/2025: 8-7 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)

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