Yankees vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:12 a.m.

The New York Yankees versus the Chicago White Sox is on the MLB schedule for Thursday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs White Sox Game Info

• New York Yankees (90-68) vs. Chicago White Sox (58-100)
• Date: Thursday, September 25, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and CHSN

Yankees vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-300) | CHW: (+245)
• Spread: NYY: -1.5 (-137) | CHW: +1.5 (+114)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Yankees vs White Sox Probable Starting Pitchers

Probable Pitchers: Carlos Rodon (Yankees) - 17-9, 3.04 ERA vs Davis Martin (White Sox) - 7-10, 4.03 ERA

The Yankees will call on Carlos Rodon (17-9) versus the White Sox and Davis Martin (7-10). Rodon's team is 13-19-0 against the spread in his starts this season. Rodon's team is 17-14 this season when he starts and they are the moneyline favorite. The White Sox have a 12-11-0 ATS record in Martin's 23 starts that had a set spread. The White Sox have a 9-14 record in Martin's 23 starts this season when they were the underdog on the moneyline.

Yankees vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (73.9%)

Yankees vs White Sox Moneyline

• Chicago is a +245 underdog on the moneyline, while New York is a -300 favorite at home.

Yankees vs White Sox Spread

• The White Sox are +1.5 on the run line against the Yankees. The White Sox are +114 to cover, and the Yankees are -137.

Yankees vs White Sox Over/Under

• The Yankees-White Sox contest on Sept. 25 has been given an over/under of 8.5 runs. The over is set at -115 and the under at -105.

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Yankees vs White Sox Betting Trends

• The Yankees have been favorites in 134 games this season and have come away with the win 81 times (60.4%) in those contests.
• New York has a record of 2-2 in contests when sportsbooks favor them by -300 or more on the moneyline.
• The Yankees and their opponents have hit the over in 75 of their 156 games with a total set by oddsmakers this season.
• In 156 games with a line this season, the Yankees have a mark of 73-83-0 against the spread.
• The White Sox have been the underdog on the moneyline 149 total times this season. They've gone 54-95 in those games.
• Chicago has played five times as a moneyline underdog with odds of +245 or longer, and lost each game.
• The White Sox have played in 153 games with a set over/under, and have combined with opponents to go over the total 70 times (70-75-8).
• The White Sox have covered 56.9% of their games this season, going 87-66-0 against the spread.

Yankees Player Leaders

• Aaron Judge leads New York with 173 hits and an OBP of .455, plus a team-best slugging percentage of .681. He's batting .328.
• Among qualifying hitters, he ranks first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 53 walks. He's batting .269 and slugging .481 with an on-base percentage of .329.
• Among all qualifying hitters, he is 41st in batting average, 72nd in on-base percentage and 29th in slugging percentage.
• Trent Grisham is batting .237 with a .472 slugging percentage and 74 RBI this year.
• Jazz Chisholm has 31 home runs, 80 RBI and a batting average of .247 this season.
• Chisholm has safely hit in six straight games. During his last 10 outings he is batting .256 with two doubles, two home runs, two walks and five RBIs.

White Sox Player Leaders

• Miguel Vargas has an on-base percentage of .312, a team-best for the White Sox. He's batting .231 and slugging .397.
• Including all the qualifying hitters in MLB, he ranks 132nd in batting average, 107th in on-base percentage and 107th in slugging percentage.
• Vargas brings a five-game hitting streak into this game. In his last five games he is batting .333 with a double, a home run, three walks and four RBIs.
• Lenyn Sosa has collected 131 hits while slugging .423. Both lead his team. He has a batting average of .259 with an on-base percentage of .288.
• His batting average ranks 69th among all qualified players, his on-base percentage is 135th, and he is 76th in slugging.
• Chase Meidroth is hitting .260 with 15 doubles, five home runs and 45 walks.
• Edgar Quero is hitting .272 with 17 doubles, five home runs and 31 walks.

Yankees vs White Sox Head to Head

• 9/24/2025: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -390, Underdog Moneyline: +310)
• 9/23/2025: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/31/2025: 3-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/30/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/29/2025: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/28/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/14/2024: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/13/2024: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 8/12/2024: 12-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -355, Underdog Moneyline: +285)
• 5/19/2024: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)

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