Cubs vs Mets Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:12 a.m.

Thursday's slate in the MLB includes a matchup between the Chicago Cubs and the New York Mets.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Mets Game Info

• Chicago Cubs (89-69) vs. New York Mets (81-77)
• Date: Thursday, September 25, 2025
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and SNY

Cubs vs Mets Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | NYM: (-100)
• Spread: CHC: +1.5 (-220) | NYM: -1.5 (+180)
• Total: 7.5 -- Over: (+114) | Under: (-140)

Cubs vs Mets Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 9-7, 3.37 ERA vs Nolan McLean (Mets) - 4-1, 1.27 ERA

The probable pitchers are Shota Imanaga (9-7) for the Cubs and Nolan McLean (4-1) for the Mets. Imanaga's team is 9-14-0 against the spread this season in his starts. Imanaga's team has been victorious in 56.2% of the games he's started as the moneyline favorite with a record of 9-7. The Mets have gone 5-2-0 ATS in McLean's seven starts that had a set spread. The Mets were named the moneyline underdog for two McLean starts this season -- they won both.

Cubs vs Mets Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mets win (52.3%)

Cubs vs Mets Moneyline

• Chicago is the favorite, -118 on the moneyline, while New York is a -100 underdog on the road.

Cubs vs Mets Spread

• The Mets are 1.5-run favorites against the spread for this matchup with the Cubs. The Mets are +180 to cover, while the Cubs are -220 to cover as a 1.5-run underdog on the runline.

Cubs vs Mets Over/Under

• A combined run total of 7.5 has been set for Cubs-Mets on Sept. 25, with the over at +114 and the under at -140.

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Cubs vs Mets Betting Trends

• The Cubs have been favorites in 105 games this season and have come away with the win 67 times (63.8%) in those contests.
• Chicago has a record of 64-31 when favored by -118 or more this year.
• The Cubs' games have gone over the total in 71 of their 153 opportunities.
• The Cubs are 72-81-0 against the spread in their 153 games that had a posted line this season.
• The Mets have gone 15-26 in games they were the underdog on the moneyline (winning 36.6% of those games).
• New York has a record of 9-18 when playing as a moneyline underdog with odds of -100 or longer (33.3%).
• The Mets have had an over/under set by bookmakers 151 times, and have combined with opponents to go over the total in 71 of those games (71-72-8).
• The Mets have put together a 70-81-0 record ATS this season (covering 46.4% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago in slugging percentage (.396) thanks to 39 extra-base hits. He has a .301 batting average and an on-base percentage of .350.
• He is seventh in batting average, 37th in on-base percentage, and 108th in slugging among all qualified batters in MLB.
• Hoerner will look for his third straight game with a hit in this contest. In his last five games he is hitting .318 with a walk and an RBI.
• Pete Crow-Armstrong is hitting .244 with 37 doubles, four triples, 29 home runs and 29 walks. He's slugging .473 with an on-base percentage of .284.
• He ranks 106th in batting average, 140th in on-base percentage and 40th in slugging in the majors.
• Ian Happ is batting .241 with a .421 slugging percentage and 78 RBI this year.
• Happ brings a three-game hitting streak into this game. During his last five outings he is hitting .238 with three doubles, a walk and five RBIs.
• Michael Busch has 131 hits, which leads Chicago hitters this season, while batting .256 with 58 extra-base hits.

Mets Player Leaders

• Juan Soto has accumulated a team-high OBP (.399), and leads the Mets in hits (150). He's batting .267 and slugging.
• Including all qualifying hitters, he ranks 43rd in batting average, while his on-base percentage is second and he is eighth in slugging.
• Soto hopes to build on an eight-game hitting streak in this matchup. In his last 10 outings he is batting .325 with two doubles, four home runs, six walks and nine RBIs.
• Francisco Lindor is slugging .459 to lead his team. He has a batting average of .267 with an on-base percentage of .342.
• Including all qualifying hitters, his batting average places him 43rd, his on-base percentage ranks 51st, and he is 47th in slugging.
• Pete Alonso is batting .271 with 38 doubles, a triple, 37 home runs and 60 walks.
• Brandon Nimmo has 27 doubles, 25 home runs and 49 walks while batting .261.

Cubs vs Mets Head to Head

• 9/24/2025: 10-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/23/2025: 9-7 NYM (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/11/2025: 6-2 NYM (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/10/2025: 6-5 CHC (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/9/2025: 7-2 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/23/2024: 5-2 NYM (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/22/2024: 8-1 CHC (Favorite: Mets, Spread: -1.5, Total: 11.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/21/2024: 11-1 NYM (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2024: 7-6 NYM (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)

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