Angels vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:11 a.m.

Thursday's slate in the MLB includes a matchup between the Los Angeles Angels and the Kansas City Royals.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Angels vs Royals Game Info

• Los Angeles Angels (71-87) vs. Kansas City Royals (79-79)
• Date: Thursday, September 25, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and FDSKC

Angels vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-108) | KC: (-108)
• Spread: LAA: +1.5 (-182) | KC: -1.5 (+150)
• Total: 9 -- Over: (-122) | Under: (-100)

Angels vs Royals Probable Starting Pitchers

Probable Pitchers: Mitch Farris (Angels) - 1-2, 6.52 ERA vs Michael Lorenzen (Royals) - 6-11, 4.70 ERA

The Angels will call on Mitch Farris (1-2) against the Royals and Michael Lorenzen (6-11). When Farris starts, his team is 2-2-0 against the spread this season. Farris' team lost his only start as a favorite this season. When Lorenzen starts, the Royals have gone 15-10-0 against the spread. The Royals have an 8-7 record in Lorenzen's 15 starts this season when they were the moneyline underdog.

Angels vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.9%)

Angels vs Royals Moneyline

• Kansas City is the underdog, -108 on the moneyline, while Los Angeles is a -108 favorite at home.

Angels vs Royals Spread

Angels vs Royals Over/Under

• The over/under for Angels-Royals on Sept. 25 is 9. The over is -122, and the under is -100.

Bet on Los Angeles Angels vs. Kansas City Royals on FanDuel today!

Angels vs Royals Betting Trends

• The Angels have won in 18, or 50%, of the 36 contests they have been named as odds-on favorites in this year.
• This year Los Angeles has won 19 of 39 games when listed as at least -108 on the moneyline.
• The Angels' games have gone over the total in 83 of their 156 opportunities.
• The Angels have an against the spread mark of 82-74-0 in 156 games with a line this season.
• The Royals have been the underdog on the moneyline 91 total times this season. They've gone 41-50 in those games.
• Kansas City has a 41-50 record (winning 45.1% of its games) when playing as a moneyline underdog of -108 or longer.
• The Royals have had an over/under set by bookmakers 156 times, and have combined with opponents to go over the total in 68 of those games (68-86-2).
• The Royals have covered 48.7% of their games this season, going 76-80-0 against the spread.

Angels Player Leaders

• Taylor Ward has an OPS of .792, fueled by an OBP of .315 and a team-best slugging percentage of .477 this season. He has a .228 batting average.
• Among qualified hitters, he is 137th in batting average, his on-base percentage ranks 104th, and he is 33rd in slugging.
• Ward has recorded at least one hit in seven straight games. In his last 10 outings he is hitting .282 with six home runs and six RBIs.
• Jo Adell leads Los Angeles with 120 hits. He is batting .235 this season and has 54 extra-base hits. He's also slugging .484 with an on-base percentage of .294.
• He ranks 120th in batting average, 129th in on-base percentage and 25th in slugging in MLB.
• Nolan Schanuel leads Los Angeles in OBP (.356) this season, fueled by 128 hits.
• Mike Trout leads Los Angeles with an OBP of .356 this season while batting .227 with 86 walks and 68 runs scored.

Royals Player Leaders

• Bobby Witt Jr. has put up a slugging percentage of .498 and has 176 hits, both team-best numbers for the Royals. He's batting .291 and with an on-base percentage of .349.
• Including all the qualifying hitters in the big leagues, his batting average places him 12th, his on-base percentage is 39th, and he is 17th in slugging.
• Maikel Garcia's .352 OBP leads his team. He has a batting average of .286 while slugging .452.
• He is currently 19th in batting average, 34th in on-base percentage and 58th in slugging percentage among all qualified batters.
• Vinnie Pasquantino is hitting .267 with 31 doubles, a triple, 31 home runs and 48 walks.
• Salvador Perez has 34 doubles, 30 home runs and 26 walks while hitting .241.

Angels vs Royals Head to Head

• 9/24/2025: 3-2 LAA (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 8-4 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/4/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/3/2025: 4-3 LAA (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/2/2025: 5-1 LAA (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 8/21/2024: 3-0 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/20/2024: 9-5 LAA (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/19/2024: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/12/2024: 4-2 KC (Favorite: Angels, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/11/2024: 9-3 LAA (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)

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