Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:12 a.m.

Thursday's slate in the MLB includes a matchup between the Cleveland Guardians and the Detroit Tigers.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Guardians vs Tigers Game Info

• Cleveland Guardians (86-72) vs. Detroit Tigers (85-73)
• Date: Thursday, September 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSDET

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-166) | DET: (+140)
• Spread: CLE: -1.5 (+126) | DET: +1.5 (-152)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 3-0, 2.08 ERA vs TBA (Tigers)

Parker Messick (3-0) take the hill for the Guardians in this matchup. The Tigers, however, have yet to list a starter. Messick and his team have a record of 4-2-0 against the spread when he starts. Messick's team has won each of the three games he's started as the moneyline favorite.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.3%)

Guardians vs Tigers Moneyline

• Detroit is the underdog, +140 on the moneyline, while Cleveland is a -166 favorite at home.

Guardians vs Tigers Spread

• The Guardians are favored by 1.5 runs at home against the Tigers. The Guardians are +126 to cover the spread, while the Tigers are -152.

Guardians vs Tigers Over/Under

• A combined run total of 7.5 has been set for Guardians-Tigers on Sept. 25, with the over at -122 and the under at -100.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have been chosen as favorites in 65 games this year and have walked away with the win 42 times (64.6%) in those games.
• This year Cleveland has won eight of nine games when listed as at least -166 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 66 of their 154 opportunities.
• The Guardians have an against the spread record of 85-69-0 in 154 games with a line this season.
• The Tigers have gone 20-21 in games they were the underdog on the moneyline (winning 48.8% of those games).
• When playing as a moneyline underdog with odds of +140 or longer, Detroit has a record of 2-3 (40%).
• The Tigers have had an over/under set by bookmakers 151 times, and have combined with opponents to go over the total in 78 of those games (78-67-6).
• The Tigers have collected a 70-81-0 record against the spread this season.

Guardians Player Leaders

• Jose Ramirez has 164 hits and an OBP of .360, both of which lead Cleveland hitters this season. He has a .284 batting average and a slugging percentage of .507.
• Among qualifying hitters in the majors, his batting average ranks 20th, his on-base percentage ranks 20th, and he is 14th in slugging.
• Ramirez will look for his eighth straight game with a hit in this contest. During his last 10 games he is batting .333 with four doubles, two home runs, seven walks and seven RBIs.
• Steven Kwan has hit 11 homers this season while driving in 56 runs. He's batting .277 this season and slugging .382 with an on-base percentage of .335.
• Among all qualified, he is 30th in batting average, 60th in on-base percentage and 121st in slugging percentage.
• Kwan takes a six-game streak with at least one hit into this contest. During his last 10 games he is batting .310 with three doubles, a home run, three walks and eight RBIs.
• Kyle Manzardo has collected 107 base hits, an OBP of .315 and a slugging percentage of .453 this season.
• Angel Martinez has been key for Cleveland with 99 hits, an OBP of .270 plus a slugging percentage of .366.

Tigers Player Leaders

• Gleyber Torres has accumulated an on-base percentage of .363, a team-best for the Tigers. He's batting .259 and slugging .394.
• Including all the qualified hitters in the big leagues, he is 69th in batting average, 15th in on-base percentage and 110th in slugging percentage.
• Riley Greene's 154 hits and .496 slugging percentage both lead his team. He has a batting average of .261 with an on-base percentage of .316.
• He is currently 63rd in batting average, 100th in on-base percentage and 18th in slugging percentage among all qualified hitters.
• Spencer Torkelson has 27 doubles, a triple, 31 home runs and 70 walks while batting .241.
• Zach McKinstry has 23 doubles, 11 triples, 12 home runs and 46 walks while hitting .260.

Guardians vs Tigers Head to Head

• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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