Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 1:11 a.m.

MLB action on Friday includes the New York Yankees facing the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Orioles Game Info

• New York Yankees (92-67) vs. Baltimore Orioles (78-81)
• Date: Friday, September 25, 2026
• Time: 4:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: FOX

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-134) | BAL: (+114)
• Spread: NYY: -1.5 (+176) | BAL: +1.5 (-215)
• Total: 6.5 -- Over: (-120) | Under: (-102)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Brendan Beck (Yankees) - 0-1, 8.22 ERA vs Trevor Rogers (Orioles) - 10-11, 4.07 ERA

This contest's pitching matchup is set, as the Yankees will send Brendan Beck (0-1) to the mound, while Trevor Rogers (10-11) will answer the bell for the Orioles. Beck and his team failed to cover the spread in his only opportunity this season as a starter. Beck's team lost his only start as a favorite this season. The Orioles are 14-15-0 ATS in Rogers' 29 starts with a set spread. The Orioles have been the moneyline underdog in nine of Rogers' starts this season, and they went 4-5 in those matchups.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (58.9%)

Yankees vs Orioles Moneyline

• New York is a -134 favorite on the moneyline, while Baltimore is a +114 underdog on the road.

Yankees vs Orioles Spread

• The Orioles are at the Yankees, and are +1.5 on the runline. The Orioles are +176 to cover the spread, and the Yankees are -215.

Yankees vs Orioles Over/Under

• Yankees versus Orioles on Sept. 25 has an over/under of 6.5 runs, with the odds on the over -120 and the under set at -102.

Bet on New York Yankees vs. Baltimore Orioles on FanDuel today!

Yankees vs Orioles Betting Trends

• The Yankees have been favorites in 123 games this season and have come away with the win 74 times (60.2%) in those contests.
• New York has a record of 52-35 when favored by -134 or more this year.
• The Yankees and their opponents have hit the over in 73 of their 154 games with a total set by oddsmakers this season.
• The Yankees have an against the spread record of 80-74-0 in 154 games with a line this season.
• The Orioles have been the underdog on the moneyline 80 total times this season. They've finished 37-43 in those games.
• Baltimore has gone 13-24 when playing as a moneyline underdog with odds of +114 or longer (35.1%).
• The Orioles have combined with opponents to hit the over on the total 79 times this season for a 79-74-4 record against the over/under.
• The Orioles have collected an 83-74-0 record ATS this season (covering 52.9% of the time).

Yankees Player Leaders

• Ben Rice leads New York in OBP (.362), slugging percentage (.535) and total hits (148) this season. He has a .262 batting average.
• He ranks 55th in batting average, 26th in on-base percentage, and third in slugging among qualified hitters in baseball.
• Luis Garcia has 26 doubles, five triples, 30 home runs and 24 walks. He's batting .277 and slugging .522 with an on-base percentage of .308.
• He is 28th in batting average, 107th in on-base percentage and fifth in slugging in the major leagues.
• Cody Bellinger has collected 131 base hits, an OBP of .341 and a slugging percentage of .433 this season.
• Jazz Chisholm has 19 home runs, 55 RBI and a batting average of .233 this season.
• Chisholm has safely hit in four straight games. In his last five games he is hitting .313 with three walks.

Orioles Player Leaders

• Pete Alonso has racked up a team-high OBP (.359) and slugging percentage (.512), while pacing the Orioles in hits (157, while batting .264).
• Including all the qualified hitters in MLB, his batting average is 50th, his on-base percentage is 31st, and he is 11th in slugging.
• Gunnar Henderson has 27 doubles, six triples, 24 home runs and 67 walks while batting .225. He's slugging .405 with an on-base percentage of .310.
• Including all qualified hitters, his batting average places him 119th, his on-base percentage is 100th, and he is 85th in slugging.
• Coby Mayo has 18 doubles, three triples, 24 home runs and 34 walks while hitting .225.
• Leody Taveras has 16 doubles, six triples, eight home runs and 41 walks while hitting .216.

Yankees vs Orioles Head to Head

• 8/20/2026: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: +100)
• 8/19/2026: 5-3 NYY (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/18/2026: 3-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -106, Underdog Moneyline: -102)
• 5/13/2026: 7-0 BAL (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/12/2026: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/11/2026: 3-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/4/2026: 12-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/3/2026: 11-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 5/2/2026: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/1/2026: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)

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