White Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 5:14 a.m.

MLB action on Sunday includes the Chicago White Sox facing the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

White Sox vs Cardinals Game Info

• Chicago White Sox (76-72) vs. St. Louis Cardinals (73-76)
• Date: Sunday, September 13, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

White Sox vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-138) | STL: (+118)
• Spread: CHW: -1.5 (+126) | STL: +1.5 (-152)
• Total: 8 -- Over: (-110) | Under: (-110)

White Sox vs Cardinals Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 8-7, 3.58 ERA vs Michael McGreevy (Cardinals) - 6-9, 3.92 ERA

The White Sox will give the ball to Sean Burke (8-7, 3.58 ERA), who is eyeing win No. 9 on the season, and the Cardinals will turn to Michael McGreevy (6-9, 3.92 ERA). Burke's team is 13-12-0 against the spread in his starts this season. Burke's team has been victorious in 70% of the games he's started as the moneyline favorite with a record of 7-3. When McGreevy starts, the Cardinals are 16-12-0 against the spread. The Cardinals are 10-10 in McGreevy's 20 starts this season that they were the moneyline underdog.

White Sox vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (50.2%)

White Sox vs Cardinals Moneyline

• St. Louis is the underdog, +118 on the moneyline, while Chicago is a -138 favorite despite being on the road.

White Sox vs Cardinals Spread

• The Cardinals are hosting the White Sox, and are +1.5 on the runline. The Cardinals are +126 to cover the spread, and the White Sox are -152.

White Sox vs Cardinals Over/Under

• A combined run total of 8 has been set for White Sox-Cardinals on Sept. 13, with the over at -110 and the under at -110.

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White Sox vs Cardinals Betting Trends

• The White Sox have come away with 19 wins in the 35 contests they have been listed as the favorites in this season.
• Chicago has a record of 5-4 in contests when sportsbooks favor them by -138 or more on the moneyline.
• The White Sox and their opponents have gone over the total this season in 80 of their 145 opportunities.
• In 145 games with a line this season, the White Sox have a mark of 81-64-0 against the spread.
• The Cardinals have won 46.3% of the games this season they were the moneyline underdog (44-51).
• St. Louis has a 21-21 record (winning 50% of its games) when playing as a moneyline underdog of +118 or longer.
• The Cardinals have played in 145 games with a set over/under, and have combined with opponents to go over the total 67 times (67-71-7).
• The Cardinals have a 79-66-0 record against the spread this season (covering 54.5% of the time).

White Sox Player Leaders

• Miguel Vargas has 30 doubles, a triple, 30 home runs and 88 walks while batting .247. He has an on-base percentage of .356 and a slugging percentage of .471.
• Among qualifying hitters, he ranks 81st in batting average, his on-base percentage ranks 35th, and he is 30th in slugging.
• Vargas will look for his third straight game with a hit in this contest. In his last five games he is hitting .100 with a walk.
• Chase Meidroth has an OPS of .744, fueled by an OBP of .345 and a team-best slugging percentage of .400 this season. He's batting .268.
• His batting average is 47th among qualified players, his on-base percentage 49th, and his slugging percentage 89th.
• Sam Antonacci leads Chicago with an OBP of .367 this season while batting .269 with 42 walks and 74 runs scored.
• Antonacci has recorded a hit in two games in a row. During his last five outings he is batting .294 with an RBI.
• Tristan Peters has 12 home runs, 54 RBI and a batting average of .279 this season.

Cardinals Player Leaders

• Alec Burleson has a slugging percentage of .465, a team-best for the Cardinals. He's batting .282 with an on-base percentage of .349.
• Including all the qualifying hitters in the big leagues, his batting average ranks 18th, his on-base percentage ranks 45th, and he is 34th in slugging.
• Jordan Walker paces his team with 159 hits and has a club-leading .490 slugging percentage. He has a batting average of .282 with an on-base percentage of .338.
• Including all qualified hitters, his batting average puts him 18th, his on-base percentage ranks 58th, and he is 21st in slugging.
• Ivan Herrera has racked up an on-base percentage of .359, a team-best for the Cardinals.
• Nathan Church is hitting .251 with 13 doubles, two triples, 10 home runs and 24 walks.

White Sox vs Cardinals Head to Head

• 9/12/2026: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/11/2026: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/19/2025: 8-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/19/2025: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)

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