Twins vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 5:13 a.m.

The Sunday schedule in MLB includes a matchup between the Minnesota Twins and the Cleveland Guardians.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Guardians Game Info

• Minnesota Twins (70-78) vs. Cleveland Guardians (75-74)
• Date: Sunday, September 13, 2026
• Time: 2:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and CleGuardians.TV

Twins vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-134) | CLE: (+116)
• Spread: MIN: -1.5 (+160) | CLE: +1.5 (-194)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Twins vs Guardians Probable Starting Pitchers

Probable Pitchers: Joe Ryan (Twins) - 6-9, 4.10 ERA vs Tanner Bibee (Guardians) - 5-15, 4.22 ERA

This contest's pitching matchup is set, as the Twins will send Joe Ryan (6-9) to the mound, while Tanner Bibee (5-15) will get the nod for the Guardians. When Ryan starts, his team is 13-10-0 against the spread this season. Ryan's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 8-8. The Guardians have a 7-21-0 record against the spread in Bibee's starts. The Guardians have been the underdog on the moneyline in 13 of Bibee's starts this season, and they went 5-8 in those games.

Twins vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (59.9%)

Twins vs Guardians Moneyline

• Looking at the moneyline for Twins-Guardians, Minnesota is the favorite at -134, and Cleveland is +116 playing on the road.

Twins vs Guardians Spread

• The Guardians are at the Twins, and are +1.5 on the runline. The Guardians are +160 to cover the spread, and the Twins are -194.

Twins vs Guardians Over/Under

• The Twins-Guardians contest on Sept. 13 has been given an over/under of 7.5 runs. The over is set at -124 and the under at +102.

Bet on Minnesota Twins vs. Cleveland Guardians on FanDuel today!

Twins vs Guardians Betting Trends

• The Twins have been favorites in 53 games this season and have come away with the win 28 times (52.8%) in those contests.
• This season Minnesota has been victorious 11 times in 21 chances when named as a favorite of at least -134 on the moneyline.
• The Twins and their opponents have gone over the total this season in 80 of their 144 opportunities.
• The Twins are 78-66-0 against the spread in their 144 games that had a posted line this season.
• The Guardians have been the underdog on the moneyline 54 total times this season. They've finished 27-27 in those games.
• In games it has played as a moneyline underdog with odds of +116 or longer, Cleveland has a 14-11 record (winning 56% of its games).
• The Guardians have had an over/under set by oddsmakers 141 times, and have combined with opponents to go over the total in 68 of those games (68-73-0).
• The Guardians are 66-75-0 ATS this season.

Twins Player Leaders

• Brooks Lee has an OPS of .731, fueled by an OBP of .298 and a team-best slugging percentage of .433 this season. He has a .249 batting average.
• Among qualifying hitters in the majors, his batting average ranks 76th, his on-base percentage ranks 121st, and he is 60th in slugging.
• Josh Bell leads Minnesota in slugging percentage (.420) thanks to 48 extra-base hits. He's batting .253 with an on-base percentage of .318.
• His batting average ranks 71st among qualified players, his on-base percentage 88th, and his slugging percentage 73rd.
• Kody Clemens leads Minnesota with 116 hits. He is batting .241 this season and 53 of his hits have gone for extra bases.
• Clemens heads into this game with five games in a row with at least one hit. During his last five outings he is hitting .316 with two home runs, two walks and four RBIs.
• Luke Keaschall leads Minnesota in OBP (.364) this season, fueled by 130 hits.

Guardians Player Leaders

• Chase DeLauter leads the Guardians with 133 hits. He's batting .291 and slugging .457 with an on-base percentage of .363.
• Including all qualified hitters in the majors, his batting average places him 12th, his on-base percentage ranks 24th, and he is 42nd in slugging.
• Steven Kwan's .371 OBP and .335 slugging percentage both lead his team. He has a batting average of .274.
• He is 31st in batting average, 13th in on-base percentage and 136th in slugging percentage in the big leagues.
• Jose Ramirez is hitting .230 with 24 doubles, 11 home runs and 57 walks.
• Brayan Rocchio has 21 doubles, two triples, 13 home runs and 34 walks while batting .246.

Twins vs Guardians Head to Head

• 9/12/2026: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/11/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/23/2026: 3-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/22/2026: 10-6 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!