Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 8:11 a.m.

MLB action on Friday includes the Minnesota Twins taking on the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Twins vs White Sox Game Info

• Minnesota Twins (58-69) vs. Chicago White Sox (45-82)
• Date: Friday, August 22, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MNNT

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-142) | CHW: (+120)
• Spread: MIN: -1.5 (+122) | CHW: +1.5 (-146)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 3-4, 5.06 ERA vs Aaron Civale (White Sox) - 3-8, 4.88 ERA

The Twins will look to Zebby Matthews (3-4) versus the White Sox and Aaron Civale (3-8). When Matthews starts, his team is 3-7-0 against the spread this season. Matthews' team is 3-3 this season when he starts and they are the moneyline favorite. The White Sox have gone 6-10-0 against the spread when Civale starts. The White Sox are 3-11 in Civale's 14 starts this season that they were the underdog on the moneyline.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (58.3%)

Twins vs White Sox Moneyline

• Looking at the moneyline for Twins-White Sox, Minnesota is the favorite at -142, and Chicago is +120 playing at home.

Twins vs White Sox Spread

• The Twins are favored by 1.5 runs on the road versus the White Sox. The Twins are +122 to cover the spread, while the White Sox are -146.

Twins vs White Sox Over/Under

• A combined run total of 8.5 has been set for Twins-White Sox on Aug. 22, with the over at -105 and the under at -115.

Bet on Minnesota Twins vs. Chicago White Sox on FanDuel today!

Twins vs White Sox Betting Trends

• The Twins have won in 37, or 50.7%, of the 73 contests they have been named as odds-on favorites in this year.
• This season Minnesota has come away with a win 18 times in 30 chances when named as a favorite of at least -142 on the moneyline.
• The Twins and their opponents have gone over the total this season in 53 of their 122 opportunities.
• The Twins are 60-62-0 against the spread in their 122 games that had a posted line this season.
• The White Sox have won 41 of the 119 games they were the underdog on the moneyline this season (34.5%).
• Chicago has a 30-64 record (winning just 31.9% of its games) when playing as a moneyline underdog of +120 or longer.
• The White Sox have had an over/under set by bookmakers 122 times, and have combined with opponents to go over the total in 54 of those games (54-60-8).
• The White Sox have a 68-54-0 record ATS this season.

Twins Player Leaders

• Byron Buxton has 99 hits, which is best among Minnesota hitters this season, while batting .270 with 44 extra-base hits. He has an on-base percentage of .332 and a slugging percentage of .538.
• He is 46th in batting average, 72nd in on-base percentage, and 10th in slugging among all qualifying hitters in MLB.
• Trevor Larnach has an OPS of .734, fueled by an OBP of .319 and a team-best slugging percentage of .415 this season. He's batting .247.
• Among qualifiers, he is 102nd in batting average, 98th in on-base percentage and 91st in slugging percentage.
• Larnach takes a four-game streak with at least one hit into this contest. In his last five games he is hitting .263 with two doubles, two walks and an RBI.
• Brooks Lee has 93 hits this season and has a slash line of .249/.294/.394.
• Ryan Jeffers leads Minnesota with an OBP of .352 this season while batting .262 with 41 walks and 44 runs scored.

White Sox Player Leaders

• Miguel Vargas has accumulated an on-base percentage of .307, a team-high for the White Sox. He's batting .231 and slugging .396.
• He ranks 139th in batting average, 119th in on-base percentage and 113th in slugging percentage among all qualifying hitters in the majors.
• Andrew Benintendi is hitting .227 with 14 doubles, two triples, 14 home runs and 32 walks. He's slugging .401 with an on-base percentage of .292.
• Lenyn Sosa has racked up a team-best slugging percentage (.444) while leading the White Sox in hits (108).
• Luis Robert is hitting .220 with 12 doubles, 13 home runs and 40 walks.

Twins vs White Sox Head to Head

• 4/24/2025: 3-0 CHW (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/23/2025: 6-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/22/2025: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 4/2/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/1/2025: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2025: 9-0 CHW (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2024: 13-7 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 8/3/2024: 6-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 8/2/2024: 10-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 7/10/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!