Dodgers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 7:15 a.m.

The MLB's Friday slate includes the Los Angeles Dodgers facing the San Diego Padres.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Padres Game Info

• Los Angeles Dodgers (73-55) vs. San Diego Padres (72-56)
• Date: Friday, August 22, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and SportsNet LA

Dodgers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-120) | SD: (+102)
• Spread: LAD: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8 -- Over: (-110) | Under: (-110)

Dodgers vs Padres Probable Starting Pitchers

Probable Pitchers: Blake Snell (Dodgers) - 3-1, 1.80 ERA vs Yu Darvish (Padres) - 2-3, 5.97 ERA

This contest's pitching matchup is set, as the Dodgers will send Blake Snell (3-1) to the mound, while Yu Darvish (2-3) will get the nod for the Padres. When Snell starts, his team is 2-3-0 against the spread this season. Snell's team has a record of 4-1 this season when he starts and they are the favorite on the moneyline. The Padres have gone 5-2-0 against the spread when Darvish starts. The Padres have a 2-2 record in Darvish's four starts this season when they were the underdog on the moneyline.

Dodgers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (51.8%)

Dodgers vs Padres Moneyline

• Looking at the moneyline for Dodgers-Padres, Los Angeles is the favorite at -120, and San Diego is +102 playing at home.

Dodgers vs Padres Spread

• The Dodgers are at the Padres and are favored by 1.5 runs on the spread. The Dodgers are +146 to cover the runline, with the Padres being -178.

Dodgers vs Padres Over/Under

• Dodgers versus Padres on Aug. 22 has an over/under of 8 runs, with the odds on the over -110 and the under set at -110.

Bet on Los Angeles Dodgers vs. San Diego Padres on FanDuel today!

Dodgers vs Padres Betting Trends

• The Dodgers have been victorious in 65, or 58.6%, of the 111 contests they have been chosen as favorites in this season.
• This year Los Angeles has won 63 of 106 games when listed as at least -120 on the moneyline.
• Contests with the Dodgers have gone over the total set by oddsmakers in 64 of 126 chances this season.
• The Dodgers have an against the spread mark of 52-74-0 in 126 games with a line this season.
• The Padres have a 27-29 record in games they were the underdog on the moneyline (winning 48.2% of those games).
• When playing as a moneyline underdog with odds of +102 or longer, San Diego has gone 23-25 (47.9%).
• The Padres have had an over/under set by oddsmakers 126 times, and have combined with opponents to go over the total in 54 of those games (54-69-3).
• The Padres have put together a 71-55-0 record against the spread this season (covering 56.3% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 138 hits and a team-best slugging percentage of .625. He's batting .285 with an on-base percentage of .393.
• Among all qualified hitters in the majors, his batting average ranks 23rd, his on-base percentage ranks sixth, and he is second in slugging.
• Ohtani has picked up at least one hit in five straight games. During his last five outings he is hitting .353 with a double, a home run, four walks and three RBIs.
• Mookie Betts is hitting .246 with 17 doubles, a triple, 13 home runs and 48 walks. He's slugging .372 with an on-base percentage of .317.
• His batting average is 110th among qualified players, his on-base percentage 104th, and his slugging percentage 139th.
• Betts has picked up a hit in four games in a row. During his last five outings he is batting .316 with a home run, four walks and an RBI.
• Freddie Freeman has 132 hits this season and has a slash line of .306/.378/.495.
• Freeman has logged a hit or more in six games in a row. During his last 10 outings he is hitting .282 with three doubles, two home runs, three walks and six RBIs.
• Andy Pages has 21 home runs, 71 RBI and a batting average of .274 this season.

Padres Player Leaders

• Manny Machado has a team-high slugging percentage (.486) and paces the Padres in hits (145). He's batting .294 and with an on-base percentage of .354.
• Including all qualifying hitters, he ranks 13th in batting average, while his on-base percentage ranks 36th and he is 29th in slugging.
• Machado heads into this matchup on a four-game hitting streak. During his last five outings he is hitting .286 with two doubles, a home run and five RBIs.
• Fernando Tatis Jr. has 25 doubles, two triples, 17 home runs and 74 walks while hitting .268. He's slugging .435 with an on-base percentage of .372.
• He is currently 52nd in batting average, 15th in on-base percentage and 78th in slugging percentage among all qualified hitters.
• Luis Arraez has 27 doubles, four triples, six home runs and 26 walks while hitting .289.
• Xander Bogaerts is batting .262 with 28 doubles, 10 home runs and 47 walks.

Dodgers vs Padres Head to Head

• 8/17/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/16/2025: 6-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/15/2025: 3-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/19/2025: 5-3 SD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 6/18/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/17/2025: 8-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 10, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/16/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/11/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/10/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 8-7 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!