Rangers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 6:12 a.m.

The Friday slate in MLB includes a matchup between the Texas Rangers and the Cleveland Guardians.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Rangers vs Guardians Game Info

• Texas Rangers (63-66) vs. Cleveland Guardians (64-62)
• Date: Friday, August 22, 2025
• Time: 8:05 p.m. ET
• Venue: Globe Life Field -- Arlington, Texas
• Coverage: RSN and CLEG

Rangers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TEX: (-166) | CLE: (+140)
• Spread: TEX: -1.5 (+125) | CLE: +1.5 (-150)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Rangers vs Guardians Probable Starting Pitchers

Probable Pitchers: Nathan Eovaldi (Rangers) - 11-3, 1.76 ERA vs Slade Cecconi (Guardians) - 5-6, 4.50 ERA

This contest's pitching matchup is set, as the Rangers will send Nathan Eovaldi (11-3) to the mound, while Slade Cecconi (5-6) will get the nod for the Guardians. Eovaldi and his team have a record of 14-7-0 against the spread when he starts. Eovaldi's team is 9-2 this season when he starts and they are the moneyline favorite. The Guardians are 9-6-0 against the spread when Cecconi starts. The Guardians have been the underdog on the moneyline in seven of Cecconi's starts this season, and they went 4-3 in those games.

Rangers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rangers win (64.4%)

Rangers vs Guardians Moneyline

• The moneyline numbers for Rangers vs. Guardians reveal Texas as the favorite (-166) and Cleveland as the underdog (+140) on the road.

Rangers vs Guardians Spread

• The Guardians are +1.5 on the run line against the Rangers. The Guardians are -150 to cover, and the Rangers are +125.

Rangers vs Guardians Over/Under

• Rangers versus Guardians, on Aug. 22, has an over/under of 7.5, with the over being -118 and the under -104.

Bet on Texas Rangers vs. Cleveland Guardians on FanDuel today!

Rangers vs Guardians Betting Trends

• The Rangers have come away with 37 wins in the 60 contests they have been listed as the favorites in this season.
• This year Texas has won 13 of 17 games when listed as at least -166 on the moneyline.
• The Rangers and their opponents have gone over the total this season in 56 of their 128 opportunities.
• The Rangers are 67-61-0 against the spread in their 128 games with a line set by sportsbooks this season.
• The Guardians have won 29 of the 68 games they were the underdog on the moneyline this season (42.6%).
• Cleveland has a 7-12 record (winning just 36.8% of its games) when playing as a moneyline underdog of +140 or longer.
• The Guardians have had an over/under set by oddsmakers 123 times, and have combined with opponents to go over the total in 56 of those games (56-63-4).
• The Guardians have a 64-59-0 record ATS this season.

Rangers Player Leaders

• Marcus Semien has an OPS of .669, fueled by an OBP of .305 and a team-best slugging percentage of .364 this season. He has a .230 batting average.
• He ranks 142nd in batting average, 121st in on-base percentage, and 146th in slugging among qualified hitters in baseball.
• Corey Seager leads Texas with 97 hits and an OBP of .370 this season. He's batting .269 and slugging .479.
• He is 48th in batting average, 17th in on-base percentage and 34th in slugging among qualifying batters.
• Seager enters this matchup looking to extend his five-game hit streak. In his last five games he is hitting .476 with three doubles, two home runs, a walk and three RBIs.
• Josh Smith has 107 hits this season and has a slash line of .262/.337/.389.
• Smith takes a two-game hitting streak into this game. During his last five outings he is hitting .167 with a walk and two RBIs.
• Wyatt Langford is batting .244 with a .335 OBP and 51 RBI for Texas this season.

Guardians Player Leaders

• Jose Ramirez has accumulated 135 hits with a .366 on-base percentage and a .517 slugging percentage, all club-bests for the Guardians. He's batting .291.
• Including all the qualifying hitters in MLB, his batting average is 17th, his on-base percentage ranks 22nd, and he is 14th in slugging.
• Ramirez takes a three-game hitting streak into this matchup. In his last five games he is hitting .176 with a home run, four walks and two RBIs.
• Steven Kwan is hitting .277 with 22 doubles, a triple, 10 home runs and 43 walks. He's slugging .390 with an on-base percentage of .336.
• He is currently 35th in batting average, 64th in on-base percentage and 121st in slugging percentage among all qualifying hitters.
• Carlos Santana is batting .226 with nine doubles, 11 home runs and 52 walks.
• Kyle Manzardo has 14 doubles, two triples, 21 home runs and 40 walks while hitting .233.

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