Diamondbacks vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 6:12 a.m.

The Friday schedule in MLB includes a matchup between the Arizona Diamondbacks and the Cincinnati Reds.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Diamondbacks vs Reds Game Info

• Arizona Diamondbacks (62-66) vs. Cincinnati Reds (67-61)
• Date: Friday, August 22, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and FDSOH

Diamondbacks vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-134) | CIN: (+114)
• Spread: ARI: -1.5 (+158) | CIN: +1.5 (-192)
• Total: 9 -- Over: (-114) | Under: (-106)

Diamondbacks vs Reds Probable Starting Pitchers

Probable Pitchers: Ryne Nelson (Diamondbacks) - 6-3, 3.58 ERA vs Zack Littell (Reds) - 9-8, 3.52 ERA

The probable starters are Ryne Nelson (6-3) for the Diamondbacks and Zack Littell (9-8) for the Reds. Nelson and his team have a record of 10-6-0 against the spread when he starts. Nelson's team has a record of 5-3 this season when he starts and they are the favorite on the moneyline. The Reds have a 12-13-0 record against the spread in Littell's starts. The Reds have been the underdog on the moneyline in 15 of Littell's starts this season, and they went 8-7 in those games.

Diamondbacks vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (57.4%)

Diamondbacks vs Reds Moneyline

• Cincinnati is the underdog, +114 on the moneyline, while Arizona is a -134 favorite at home.

Diamondbacks vs Reds Spread

• The Reds are at +1.5 on the runline against the Diamondbacks. The Reds are -192 to cover the spread, and the Diamondbacks are +158.

Diamondbacks vs Reds Over/Under

• Diamondbacks versus Reds, on Aug. 22, has an over/under of 9, with the over being -114 and the under -106.

Bet on Arizona Diamondbacks vs. Cincinnati Reds on FanDuel today!

Diamondbacks vs Reds Betting Trends

• The Diamondbacks have won in 39, or 51.3%, of the 76 contests they have been named as odds-on favorites in this year.
• This season Arizona has been victorious 23 times in 44 chances when named as a favorite of at least -134 on the moneyline.
• The Diamondbacks' games have gone over the total in 61 of their 124 opportunities.
• The Diamondbacks are 58-66-0 against the spread in their 124 games that had a posted line this season.
• The Reds have won 34 of the 67 games they were listed as the moneyline underdog this season (50.7%).
• Cincinnati has a record of 14-22 when playing as a moneyline underdog with odds of +114 or longer (38.9%).
• In the 121 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 47 times (47-69-5).
• The Reds have a 65-56-0 record ATS this season (covering 53.7% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo has an OPS of .826, fueled by an OBP of .388 and a team-best slugging percentage of .439 this season. He has a .287 batting average.
• He ranks 21st in batting average, seventh in on-base percentage, and 75th in slugging among all qualified hitters in the majors.
• Corbin Carroll has 113 hits, which leads Arizona batters this season. He's batting .253 with 65 extra-base hits. He's also slugging .556 with an on-base percentage of .328.
• Among qualified hitters, his batting average places him 94th, his on-base percentage 81st, and his slugging percentage fifth.
• Carroll has picked up at least one hit in eight games in a row. During his last 10 outings he is hitting .293 with a double, two triples, two home runs, five walks and five RBIs.
• Ketel Marte leads Arizona with an OBP of .394 this season while batting .293 with 55 walks and 70 runs scored.
• Lourdes Gurriel Jr. is batting .249 with a .298 OBP and 71 RBI for Arizona this season.
• Gurriel takes a seven-game hitting streak into this game. During his last 10 games he is hitting .250 with a double, three home runs, three walks and 12 RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up a team-high slugging percentage (.455) and paces the Reds in hits (135). He's batting .273 and with an on-base percentage of .347.
• Including all the qualified players in the majors, his batting average puts him 42nd, his on-base percentage ranks 45th, and he is 60th in slugging.
• TJ Friedl's .367 OBP paces his team. He has a batting average of .267 while slugging .382.
• Including all qualified hitters, he is 53rd in batting average, 20th in on-base percentage and 133rd in slugging percentage.
• Spencer Steer is batting .238 with 17 doubles, two triples, 15 home runs and 38 walks.
• Gavin Lux is batting .277 with 21 doubles, a triple, five home runs and 43 walks.

Diamondbacks vs Reds Head to Head

• 6/8/2025: 4-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 13-1 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/15/2024: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/14/2024: 6-2 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/13/2024: 6-5 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/9/2024: 5-4 ARI (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/8/2024: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/7/2024: 6-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/27/2023: 5-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/26/2023: 8-7 CIN (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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