Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:16 a.m.

The Minnesota Twins are among the MLB teams in action on Tuesday, versus the Chicago White Sox.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs White Sox Game Info

• Minnesota Twins (7-15) vs. Chicago White Sox (5-17)
• Date: Tuesday, April 22, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CHSN

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-245) | CHW: (+200)
• Spread: MIN: -1.5 (-118) | CHW: +1.5 (-102)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Bailey Ober (Twins) - 1-1, 6.16 ERA vs Davis Martin (White Sox) - 1-2, 4.84 ERA

The Twins will give the nod to Bailey Ober (1-1) against the White Sox and Davis Martin (1-2). Ober and his team have a record of 2-2-0 against the spread when he starts. Ober's team is 1-1 this season when he starts and they're favored on the moneyline. When Martin starts, the White Sox have gone 2-2-0 against the spread. The White Sox are 1-3 in Martin's four starts this season that they were the moneyline underdog.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (70.9%)

Twins vs White Sox Moneyline

• Minnesota is a -245 favorite on the moneyline, while Chicago is a +200 underdog on the road.

Twins vs White Sox Spread

• The White Sox are at the Twins, and are +1.5 on the runline. The White Sox are -118 to cover the spread, and the Twins are -102.

Twins vs White Sox Over/Under

• An over/under of 8.5 has been set for Twins-White Sox on April 22, with the over being -110 and the under -110.

Bet on Minnesota Twins vs. Chicago White Sox on FanDuel today!

Twins vs White Sox Betting Trends

• The Twins have come away with six wins in the 15 contests they have been listed as the favorites in this season.
• Oddsmakers have given Minnesota the best odds of winning it has seen this season, with a -245 moneyline listed for this contest.
• The Twins and their opponents have gone over the total this season in eight of their 22 opportunities.
• In 22 games with a line this season, the Twins have a mark of 9-13-0 against the spread.
• The White Sox have won five of the 22 games they were the moneyline underdog this season (22.7%).
• In games it has played as a moneyline underdog with odds of +200 or longer, Chicago has a 1-2 record (winning just 33.3% of its games).
• The White Sox have played in 22 games with an over/under set, and have combined with opponents to go over the total nine times (9-11-2).
• The White Sox have collected an 11-11-0 record against the spread this season.

Twins Player Leaders

• Byron Keiron Buxton leads Minnesota with 19 hits and a team-best slugging percentage of .474. He's batting .244 with an on-base percentage of .277.
• Among qualifying hitters in MLB, he is 81st in batting average, 125th in on-base percentage, and 49th in slugging.
• Buxton hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .409 with a double, a triple, a home run and three RBI.
• Ty France leads Minnesota in OBP (.314) this season, fueled by 18 hits. He's batting .234 while slugging .351.
• Among qualified hitters, his batting average places him 92nd, his on-base percentage 95th, and his slugging percentage 118th.
• Harrison Joseph Bader has 14 hits this season and has a slash line of .250/.311/.429.
• Carlos Javier Correa is batting .194 with a .256 OBP and five RBI for Minnesota this season.
• Correa heads into this game on a four-game hitting streak. During his last five outings he is hitting .294 with a double, a home run, a walk and two RBI.

White Sox Player Leaders

• Andrew Sebastian Benintendi has four home runs and four walks while batting .245. He's slugging .490 with an on-base percentage of .302.
• Luis Robert has a double, two home runs and 12 walks while hitting .145. He's slugging .246 with an on-base percentage of .268.
• Including all qualified hitters, he ranks 171st in batting average, 137th in on-base percentage and 165th in slugging percentage.
• Matt Thaiss is hitting .222 with two doubles, a home run and nine walks.
• Brooks Baldwin is batting .254 with two doubles, two home runs and a walk.

Twins vs White Sox Head to Head

• 4/2/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/1/2025: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2025: 9-0 CHW (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2024: 13-7 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 8/3/2024: 6-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 8/2/2024: 10-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 7/10/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/10/2024: 3-1 CHW (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/8/2024: 8-6 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/1/2024: 10-5 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)

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