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Giants vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 22

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Giants vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 9:11 p.m.

In MLB action on Tuesday, the San Francisco Giants take on the Milwaukee Brewers.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Giants vs Brewers Game Info

  • San Francisco Giants (15-8) vs. Milwaukee Brewers (12-11)
  • Date: Tuesday, April 22, 2025
  • Time: 9:45 p.m. ET
  • Venue: Oracle Park -- San Francisco, California
  • Coverage: NBCS-BA and FDSWIX

Giants vs Brewers Odds & Moneyline

  • All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
  • Moneyline: SF: (-142) | MIL: (+120)
  • Spread: SF: -1.5 (+150) | MIL: +1.5 (-182)
  • Total: 8 -- Over: (-108) | Under: (-112)

Giants vs Brewers Probable Starting Pitchers

Probable Pitchers: Jordan Hicks (Giants) - 1-2, 6.04 ERA vs José Quintana (Brewers) - 2-0, 0.71 ERA

This contest's pitching matchup is set, as the Giants will send Jordan Hicks (1-2) to the mound, while Jose Quintana (2-0) will get the nod for the Brewers. Hicks and his team are 2-2-0 ATS this season when he starts. Hicks' team won his only start as a favorite this season. Quintana has started two games with set spreads, and the Brewers covered in both opportunities. The Brewers were the moneyline underdog for one Quintana start this season -- they won.

Giants vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (50.2%)

Giants vs Brewers Moneyline

  • San Francisco is a -142 favorite on the moneyline, while Milwaukee is a +120 underdog on the road.

Giants vs Brewers Spread

  • The Brewers are +1.5 on the spread (-182 to cover), and San Francisco is +150 to cover the runline.

Giants vs Brewers Over/Under

  • Giants versus Brewers on April 22 has an over/under of 8 runs, with the odds on the over -108 and the under set at -112.

Bet on San Francisco Giants vs. Milwaukee Brewers on FanDuel today!

Giants vs Brewers Betting Trends

  • The Giants have been favorites in 12 games this season and have come away with the win nine times (75%) in those contests.
  • San Francisco has a record of 2-2 when favored by -142 or more this year.
  • The Giants and their opponents have gone over the total this season in 14 of their 23 opportunities.
  • The Giants have posted a record of 13-10-0 against the spread this season.
  • The Brewers have won 22.2% of the games this season they were the underdog on the moneyline (2-7).
  • Milwaukee is 1-5 (winning just 16.7% of its games) when it has played as a moneyline underdog of +120 or longer.
  • The Brewers have had an over/under set by oddsmakers 23 times, and have combined with opponents to go over the total in nine of those games (9-14-0).
  • The Brewers have a 12-11-0 record ATS this season.

Giants Player Leaders

  • Jung Hoo Lee leads San Francisco in slugging percentage (.600) and total hits (28) this season. He's batting .329 with an on-base percentage of .383.
  • Among the qualifying batters in the majors, his batting average ranks 13th, his on-base percentage ranks 30th, and he is 12th in slugging.
  • Wilmer Flores has seven home runs and five walks. He's batting .220 and slugging .476 with an on-base percentage of .273.
  • He is 112th in batting average, 133rd in on-base percentage and 48th in slugging in MLB.
  • Matt James Chapman has 18 hits this season and has a slash line of .231/.400/.423.
  • Mike Yastrzemski leads San Francisco in OBP (.423) this season, fueled by 18 hits.
  • Yastrzemski takes a two-game hitting streak into this game. During his last five outings he is hitting .250 with two doubles, four walks and two RBI.

Brewers Player Leaders

  • Jackson Chourio has racked up 26 hits, a team-best for the Brewers. He's batting .260 and slugging .510 with an on-base percentage of .272.
  • Including all qualifying players in the big leagues, his batting average places him 74th, his on-base percentage is 134th, and he is 31st in slugging.
  • Brice Turang paces his team with a .418 slugging percentage. He has a batting average of .308 with an on-base percentage of .343.
  • Including all qualified hitters, he is 24th in batting average, 66th in on-base percentage and 82nd in slugging percentage.
  • Sal Frelick a has .424 on-base percentage to lead the Brewers.
  • William Jesus (Castillo) Contreras has two doubles, three home runs and 14 walks while batting .247.

Giants vs Brewers Head to Head

  • 4/21/2025: 5-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
  • 9/12/2024: 3-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
  • 9/11/2024: 13-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
  • 9/10/2024: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
  • 8/29/2024: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
  • 8/28/2024: 5-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
  • 8/27/2024: 5-4 SF (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
  • 5/28/2023: 7-5 MIL (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
  • 5/27/2023: 3-1 SF (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
  • 5/26/2023: 15-1 SF (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)

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