Twins vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 1:12 a.m.

In MLB action on Wednesday, the Minnesota Twins face the Washington Nationals.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs Nationals Game Info

• Minnesota Twins (16-20) vs. Washington Nationals (16-20)
• Date: Wednesday, May 6, 2026
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Twins.TV

Twins vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-142) | WSH: (+120)
• Spread: MIN: -1.5 (+116) | WSH: +1.5 (-138)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Twins vs Nationals Probable Starting Pitchers

Probable Pitchers: Bailey Ober (Twins) - 3-1, 3.55 ERA vs Miles Mikolas (Nationals) - 0-3, 8.23 ERA

The probable pitchers are Bailey Ober (3-1) for the Twins and Miles Mikolas (0-3) for the Nationals. Ober's team is 4-3-0 against the spread in his starts this season. Ober's team is 1-1 this season when he starts and they're favored on the moneyline. The Nationals have gone 1-3-0 against the spread when Mikolas starts. The Nationals have been the moneyline underdog in four of Mikolas' starts this season, and they went 1-3 in those games.

Twins vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.7%)

Twins vs Nationals Moneyline

• Looking at the moneyline for Twins-Nationals, Minnesota is the favorite at -142, and Washington is +120 playing at home.

Twins vs Nationals Spread

• The Nationals are +1.5 on the run line against the Twins. The Nationals are -138 to cover, and the Twins are +116.

Twins vs Nationals Over/Under

• The over/under for Twins-Nationals on May 6 is 9.5. The over is -105, and the under is -115.

Bet on Minnesota Twins vs. Washington Nationals on FanDuel today!

Twins vs Nationals Betting Trends

• The Twins have been chosen as favorites in 10 games this year and have walked away with the win four times (40%) in those games.
• Minnesota has played as a favorite of -142 or more just one time this year and came away with a loss in that game.
• The Twins and their opponents have hit the over in 22 of their 36 games with a total set by oddsmakers this season.
• The Twins are 18-18-0 against the spread in their 36 games that had a posted line this season.
• The Nationals have won 45.7% of the games this season they were the underdog on the moneyline (16-19).
• When playing as a moneyline underdog with odds of +120 or longer, Washington has a 14-13 record (winning 51.9% of its games).
• The Nationals have played in 36 games with an over/under set, and have combined with opponents to go over the total 22 times (22-12-2).
• The Nationals have a 19-17-0 record against the spread this season.

Twins Player Leaders

• Byron Buxton leads Minnesota in slugging percentage (.536) and total hits (35) this season. He's batting .250 with an on-base percentage of .307.
• Among all qualifying hitters, he is 86th in batting average, his on-base percentage ranks 124th, and he is 18th in slugging.
• Ryan Jeffers is batting .286 with three doubles, a triple, four home runs and 16 walks, while slugging .473 with an on-base percentage of .394.
• Brooks Lee leads Minnesota in OBP (.323) this season, fueled by 31 hits.
• Lee has recorded a hit in four straight games. In his last five games he is hitting .350 with two doubles and four RBIs.
• Luke Keaschall is batting .227 with a .297 OBP and 15 RBI for Minnesota this season.
• Keaschall has safely hit in three games in a row. During his last five outings he is batting .267 with three doubles, five walks and two RBIs.

Nationals Player Leaders

• C.J. Abrams has accumulated 35 hits with a .395 on-base percentage and a .516 slugging percentage, all club-highs for the Nationals. He's batting .287.
• Including all qualifying hitters in MLB, he ranks 36th in batting average, 15th in on-base percentage and 24th in slugging percentage.
• James Wood has eight doubles, 10 home runs and 31 walks while hitting .232. He's slugging .507 with an on-base percentage of .380.
• He ranks 118th in batting average, 30th in on-base percentage and 27th in slugging percentage in MLB.
• Daylen Lile has a .376 slugging percentage, which paces the Nationals.
• Curtis Mead has six doubles, four home runs and nine walks while batting .227.

Twins vs Nationals Head to Head

• 5/5/2026: 11-3 MIN (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 7-2 WSH (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/26/2025: 9-3 WSH (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 7/25/2025: 1-0 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/22/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/21/2024: 10-0 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/20/2024: 12-3 WSH (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/23/2023: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/22/2023: 10-4 WSH (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 4/21/2023: 3-2 WSH (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

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