Tigers vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 1:11 a.m.

MLB action on Wednesday includes the Detroit Tigers facing the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Tigers vs Red Sox Game Info

• Detroit Tigers (18-19) vs. Boston Red Sox (15-21)
• Date: Wednesday, May 6, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and NESN

Tigers vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-116) | BOS: (-102)
• Spread: DET: +1.5 (-205) | BOS: -1.5 (+168)
• Total: 8 -- Over: (-110) | Under: (-110)

Tigers vs Red Sox Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 0-2, 5.90 ERA vs Sonny Gray (Red Sox) - 2-1, 4.30 ERA

The Tigers will look to Jack Flaherty (0-2) versus the Red Sox and Sonny Gray (2-1). Flaherty and his team have a record of 2-5-0 against the spread when he starts. Flaherty's team has a record of 2-3 this season when he starts and they are the favorite on the moneyline. The Red Sox have a 3-2-0 ATS record in Gray's five starts with a set spread. The Red Sox have always been the moneyline underdog when Gray starts this season.

Tigers vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (64.2%)

Tigers vs Red Sox Moneyline

• Boston is the underdog, -102 on the moneyline, while Detroit is a -116 favorite at home.

Tigers vs Red Sox Spread

• The Red Sox are 1.5-run favorites against the spread for this matchup with the Tigers. The Red Sox are +168 to cover, while the Tigers are -205 to cover as a 1.5-run underdog on the runline.

Tigers vs Red Sox Over/Under

• Tigers versus Red Sox, on May 6, has an over/under of 8, with the over being -110 and the under -110.

Bet on Detroit Tigers vs. Boston Red Sox on FanDuel today!

Tigers vs Red Sox Betting Trends

• The Tigers have been favorites in 24 games this season and have come away with the win 13 times (54.2%) in those contests.
• Detroit has a record of 13-9 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Tigers and their opponents have gone over the total this season in 18 of their 37 opportunities.
• In 37 games with a line this season, the Tigers have a mark of 19-18-0 against the spread.
• The Red Sox have a 4-8 record in games they were the underdog on the moneyline (winning 33.3% of those games).
• In games it has played as a moneyline underdog with odds of -102 or longer, Boston has a 4-7 record (winning only 36.4% of its games).
• The Red Sox have played in 36 games with a set over/under, and have combined with their opponents to go over the total 18 times (18-17-1).
• The Red Sox have covered only 33.3% of their games this season, going 12-24-0 against the spread.

Tigers Player Leaders

• Kevin McGonigle leads Detroit OPS (.869) this season. He has a .308 batting average, an on-base percentage of .403, and a slugging percentage of .466.
• Among the qualifying hitters in the majors, his batting average ranks 19th, his on-base percentage ranks 12th, and he is 46th in slugging.
• Riley Greene has nine doubles, four home runs and 22 walks. He's batting .290 and slugging .450 with an on-base percentage of .392.
• His batting average ranks 33rd among qualified players, his on-base percentage 17th, and his slugging percentage 51st.
• Greene takes a two-game streak with at least one hit into this matchup. In his last five games he is batting .333 with a double, two walks and an RBI.
• Dillon Dingler leads Detroit with 28 hits. He is batting .257 this season and 13 of his hits have gone for extra bases.
• Dingler brings a five-game hitting streak into this matchup. In his last five games he is batting .333 with two doubles, a home run and seven RBIs.
• Gleyber Torres has two home runs, 11 RBI and a batting average of .259 this season.

Red Sox Player Leaders

• Wilyer Abreu has a team-high OBP (.393) and slugging percentage (.485). He's batting .311.
• He is 18th in batting average, 16th in on-base percentage and 39th in slugging percentage among all qualifying hitters in MLB.
• Willson Contreras has 34 hits to lead his team. He has a batting average of .270 while slugging .492 with an on-base percentage of .382.
• He is 52nd in batting average, 26th in on-base percentage and 33rd in slugging percentage in the big leagues.
• Jarren Duran has five doubles, four home runs and eight walks while hitting .195.
• Ceddanne Rafaela has four doubles, two triples, two home runs and six walks while hitting .276.

Tigers vs Red Sox Head to Head

• 5/5/2026: 10-3 BOS (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/4/2026: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/20/2026: 8-6 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 6-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/18/2026: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/17/2026: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2025: 4-3 BOS (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/27/2025: 2-1 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/26/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)

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